The Arizona Cardinals are 9-12-2 against the spread as underdogs against the 49ers on the road since 1970.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 9/14/1980 | 0-0-1 |  STL | @ |  SF | L 21-24 | +3 | 0 (P) | 42 | +3 (O) | 3 | 21 | 342 | 392 | ||||
| 2 | | Cardinals | 11/9/1986 | 0-1 | STL | @ | SF | L 17-43 | +11 | -15 (N) | 40.5 | +19.5 (O) | 2 | 22 | 364 | 460 | ||||
| 3 |  | Cardinals | 11/17/1991 | 1-0 |  PHX | @ | SF | L 10-14 | +11.5 | +7.5 (Y) | 32 | -8 (U) | 1 | 13 | 176 | 257 | 20.0 | 0.0 | ||
| 4 | | Cardinals | 10/24/1993 | 0-1 | PHX | @ | SF | L 14-28 | +11.5 | -2.5 (N) | 43 | -1 (U) | 2 | 25 | 429 | 428 | 58.8 | 66.7 | ||
| 5 |  | Cardinals | 10/1/2000 | 0-1 |  ARI | @ | SF | L 20-27 | +3.5 | -3.5 (N) | 47 | 0 (P) | 2 | 16 | 365 | 345 | 23.1 | 66.7 | ||
| 6 | | Cardinals | 10/27/2002 | 0-1 | ARI | @ | SF | L 28-38 | +8 | -2 (N) | 40.5 | +25.5 (O) | 4 | 23 | 420 | 357 | 75.0 | 100.0 | ||
| 7 | | Cardinals | 12/7/2003 | 0-1 | ARI | @ | SF | L 14-50 | +10 | -26 (N) | 41 | +23 (O) | 2 | 18 | 210 | 496 | 21.4 | 66.7 | ||
| 8 | | Cardinals | 10/10/2004 | 0-1 | ARI | @ | SF | L 28-31 | +1 | -2 (N) | 36.5 | +22.5 (O) | 4 | 19 | 320 | 448 | 35.7 | 100.0 | ||
| 9 | | Cardinals | 12/24/2006 | 1-0 | ARI | +165 | @ | SF | -185 | W 26-20 | +4 | +10 (Y) | 45 | +1 (O) | 2 | 21 | 372 | 223 | 50.0 | 100.0 |
| 10 | | Cardinals | 9/10/2007 | 0-0-1 | ARI | +170 | @ | SF | -195 | L 17-20 | +3 | 0 (P) | 45 | -8 (U) | 2 | 20 | 261 | 194 | 40.0 | |
| 11 | | Cardinals | 1/2/2011 | 0-1 | ARI | +210 | @ | SF | -250 | L 7-38 | +6.5 | -24.5 (N) | 39 | +6 (O) | 1 | 19 | 279 | 362 | 45.0 | 0.0 |
| 12 | | Cardinals | 11/20/2011 | 0-1 | ARI | +450 | @ | SF | -600 | L 7-23 | +10 | -6 (N) | 41 | -11 (U) | 1 | 11 | 229 | 431 | 11.1 | 0.0 |
| 13 | | Cardinals | 12/30/2012 | 1-0 | ARI | +1000 | @ | SF | -1600 | L 13-27 | +16.5 | +2.5 (Y) | 38.5 | +1.5 (O) | 1 | 11 | 262 | 407 | 25.0 | 100.0 |
| 14 | | Cardinals | 10/13/2013 | 0-1 | ARI | +400 | @ | SF | -550 | L 20-32 | +10 | -2 (N) | 40.5 | +11.5 (O) | 3 | 16 | 403 | 387 | 38.5 | 0.0 |
| 15 | | Cardinals | 12/28/2014 | 1-0 | ARI | +240 | @ | SF | -300 | L 17-20 | +6 | +3 (Y) | 38 | -1 (U) | 2 | 26 | 397 | 395 | 40.0 | |
| 16 | | Cardinals | 10/7/2018 | 1-0 | ARI | +146 | @ | SF | -156 | W 28-18 | +3 | +13 (Y) | 40.5 | +5.5 (O) | 4 | 10 | 220 | 447 | 16.7 | |
| 17 | | Cardinals | 11/17/2019 | 0-1 | ARI | +351 | @ | SF | -470 | L 26-36 | +9.5 | -0.5 (N) | 44 | +18 (O) | 3 | 21 | 266 | 442 | 30.0 | 100.0 |
| 18 | | Cardinals | 9/13/2020 | 1-0 | ARI | +245 | @ | SF | -312 | W 24-20 | +6.5 | +10.5 (Y) | 48 | -4 (U) | 3 | 29 | 404 | 366 | 50.0 | |
| 19 | | Cardinals | 11/7/2021 | 1-0 | ARI | +199 | @ | SF | -247 | W 31-17 | +5.5 | +19.5 (Y) | 44.5 | +3.5 (O) | 4 | 22 | 437 | 337 | 46.7 | 50.0 |
| 20 | | Cardinals | 1/8/2023 | 0-1 | ARI | +693 | @ | SF | -1057 | L 13-38 | +14.5 | -10.5 (N) | 39.5 | +11.5 (O) | 2 | 11 | 255 | 311 | 40.0 | 0.0 |
| 21 | | Cardinals | 10/1/2023 | 0-1 | ARI | +692 | @ | SF | -1106 | L 16-35 | +14.5 | -4.5 (N) | 44 | +7 (O) | 2 | 23 | 362 | 395 | 53.3 | 66.7 |
| 22 | | Cardinals | 10/6/2024 | 1-0 | ARI | +278 | @ | SF | -350 | W 24-23 | +7.5 | +8.5 (Y) | 48.5 | -1.5 (U) | 2 | 19 | 358 | 384 | 30.0 | 100.0 |
| 23 | | Cardinals | 9/21/2025 | 1-0 | ARI | +103 | @ | SF | -123 | L 15-16 | +1.5 | +0.5 (Y) | 44.5 | -13.5 (U) | 1 | 16 | 260 | 355 | 33.3 | 100.0 |
| Average | 1.9 | 2.3 | 18.8 | 321.3 | 374.7 | |||||||||||||||
| Total | 9-12-2 | 53 | 432 | 7,391 | 8,619 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More Cardinals Stats
Team Rankings
PPG
20.6
23rd
OPP PPG
19.2
4th
RUSH YDS/G
118.2
13th
PASS YDS/G
192.4
30th
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 2 | 0 | .600 |
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