The Arizona Cardinals are 1-3 against the spread as underdogs versus the Bills on the road since 1970.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 9/21/1986 | 0-1 | @ | L 10-17 | +3.5 | -3.5 (N) | 47 | -20 (U) | 1 | 25 | 381 | 176 | ||||||
| 2 |  | Cardinals | 11/11/1990 | 0-1 | @ | L 14-45 | +12 | -19 (N) | 36 | +23 (O) | 2 | 11 | 127 | 360 | ||||||
| 3 |  | Cardinals | 10/31/2004 | 0-1 | @ | L 14-38 | +3.5 | -20.5 (N) | 33.5 | +18.5 (O) | 2 | 14 | 213 | 209 | 25.0 | 50.0 | ||||
| 4 | | Cardinals | 9/8/2024 | 1-0 | +246 | @ | -308 | L 28-34 | +6.5 | +0.5 (Y) | 45.5 | +16.5 (O) | 3 | 18 | 270 | 352 | 53.8 | 0.0 | ||
| Average | 6.3 | 2.0 | 17.0 | 247.8 | 274.3 | |||||||||||||||
| Total | 1-3 | 8 | 68 | 991 | 1,097 |
STL
PHXStatMuse has team, game-level data for spread records going back to the 1979 season.
More Cardinals Stats
Team Leaders 
PASS
3,366
Brissett
RUSH
333
Carter
REC
1,239
McBride
Team Rankings
PPG
20.9
23rd
OPP PPG
28.7
29th
RUSH YDS/G
93.1
31st
PASS YDS/G
256.1
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
