The Carolina Panthers had their lowest point differential in a game versus the Oakland Raiders on December 24, 2000, with a -43-point differential.
Interpreted as:
carolina panthers biggest loss in a regular-season game ever| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Panthers | -43 | 12/24/2000 | @ | L 9-52 | 0 | 19 | 297 | 409 | 50.0 | |||
| 2 | | Panthers | -41 | 11/24/2002 | vs | L 0-41 | 0 | 10 | 122 | 426 | 20.0 | |||
| 3 | | Panthers | -38 | 10/27/2019 | @ | L 13-51 | 1 | 12 | 230 | 388 | 15.4 | 0.0 | ||
| 4 | | Panthers | -37 | 9/8/2024 | @ | L 10-47 | 1 | 11 | 193 | 379 | 10.0 | 33.3 | ||
| 5 | | Panthers | -34 | 12/29/2024 | @ | L 14-48 | 2 | 13 | 204 | 551 | 22.2 | 0.0 | ||
| 6 | | Panthers | -34 | 12/17/2006 | vs | L 3-37 | 0 | 12 | 240 | 306 | 23.1 | 50.0 | ||
| 7 | | Panthers | -34 | 11/11/2001 | @ | L 14-48 | 2 | 8 | 146 | 493 | 9.1 | 0.0 | ||
| 8 | | Panthers | -34 | 11/9/1997 | @ | L 0-34 | 0 | 7 | 147 | 393 | 23.1 | |||
| 9 | | Panthers | -33 | 10/20/2024 | @ | L 7-40 | 1 | 10 | 180 | 421 | 30.0 | 0.0 | ||
| 10 | | Panthers | -33 | 12/4/2016 | @ | L 7-40 | 1 | 14 | 271 | 534 | 41.7 | 0.0 | ||
| 11 | | Panthers | -32 | 12/29/2019 | vs | L 10-42 | 1 | 16 | 329 | 379 | 31.3 | 50.0 | ||
| 12 | | Panthers | -32 | 12/22/2019 | @ | L 6-38 | 0 | 19 | 286 | 324 | 28.6 | 50.0 | ||
| 13 | | Panthers | -32 | 1/6/2002 | vs | L 6-38 | 0 | 18 | 322 | 298 | 30.8 | 0.0 | ||
| 14 | | Panthers | -31 | 10/26/2025 | vs | L 9-40 | 1 | 19 | 244 | 410 | 36.4 | 100.0 | ||
| 15 | | Panthers | -31 | 11/8/2018 | @ | L 21-52 | 3 | 18 | 242 | 457 | 36.4 | 100.0 | ||
| 16 | | Panthers | -31 | 11/7/2010 | vs | L 3-34 | 0 | 15 | 195 | 408 | 8.3 | 50.0 | ||
| 17 | | Panthers | -31 | 12/9/2007 | @ | L 6-37 | 0 | 10 | 149 | 427 | 16.7 | 33.3 | ||
| 18 | | Panthers | -30 | 10/20/2002 | @ | L 0-30 | 0 | 12 | 205 | 393 | 27.3 | 0.0 | ||
| 19 | | Panthers | -29 | 9/28/2025 | @ | L 13-42 | 2 | 21 | 326 | 307 | 35.7 | 33.3 | ||
| 20 | | Panthers | -29 | 9/20/2012 | vs | L 7-36 | 1 | 22 | 327 | 405 | 44.4 | 0.0 | ||
| 21 | | Panthers | -28 | 9/28/2014 | @ | L 10-38 | 1 | 20 | 315 | 454 | 66.7 | |||
| 22 | | Panthers | -28 | 1/1/2012 | @ | L 17-45 | 2 | 21 | 301 | 617 | 0.0 | |||
| 23 | | Panthers | -28 | 9/13/2009 | vs | L 10-38 | 1 | 14 | 169 | 267 | 18.8 | 66.7 | ||
| 24 | | Panthers | -28 | 10/4/1998 | @ | L 23-51 | 3 | 16 | 346 | 323 | 33.3 | 50.0 | ||
| 25 | | Panthers | -27 | 11/13/2011 | vs | L 3-30 | 0 | 16 | 279 | 383 | 21.4 | |||
STLMore Panthers Stats
Team Leaders 
PASS
3,011
Young
RUSH
1,076
Dowdle
REC
1,014
McMillan
Team Rankings
PPG
18.3
27th
OPP PPG
22.4
15th
RUSH YDS/G
116.3
19th
PASS YDS/G
194.4
27th
2025 Division Standings
| TEAM | W | L | T | PCT |
|---|---|---|---|---|
8 | 9 | 0 | .471 | |
8 | 9 | 0 | .471 | |
 Panthers | 8 | 9 | 0 | .471 |
6 | 11 | 0 | .353 |
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
| Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |