21 players played in 1 game. The first three are LaDainian Tomlinson 19 times, Gary Anderson on December 18, 1988, on December 11, 1988 and on November 13, 1988 and Melvin Gordon on November 6, 2016.
| NAME | GP | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Tomlinson | 1 | 243 | 12/28/2003 | vs | 31 | 7.8 | 2 | 17 | 8 | 15 | 2.1 | 0 | ||
| 2 | | L. Tomlinson | 1 | 220 | 12/1/2002 | vs | 37 | 5.9 | 3 | 51 | 11 | 14 | 4.6 | 0 | ||
| 3 | | L. Tomlinson | 1 | 217 | 9/29/2002 | vs | 27 | 8.0 | 2 | 20 | 4 | 6 | 5.0 | 0 | ||
| 4 |  | G. Anderson | 1 | 217 | 12/18/1988 | vs | 34 | 6.4 | 1 | 0 | 0 | 0 | ||||
| 5 | | L. Tomlinson | 1 | 200 | 10/19/2003 | @ | 26 | 7.7 | 1 | 21 | 3 | 4 | 7.0 | 0 | ||
| 6 | | L. Tomlinson | 1 | 199 | 12/17/2006 | vs | 25 | 8.0 | 2 | 5 | 1 | 2 | 5.0 | 0 | ||
| 7 | | L. Tomlinson | 1 | 198 | 10/14/2007 | vs | 24 | 8.3 | 4 | 16 | 3 | 4 | 5.3 | 0 | ||
| 8 |  | M. Gordon | 1 | 196 | 11/6/2016 | vs | 32 | 6.1 | 1 | 65 | 4 | 4 | 16.3 | 0 | ||
| 9 | | L. Tomlinson | 1 | 192 | 9/25/2005 | vs | 21 | 9.1 | 3 | 28 | 6 | 7 | 4.7 | 0 | ||
| 10 | | B. Hubbert | 1 | 189 | 12/24/1967 | vs | 15 | 12.6 | 2 | 8 | 1 | 8.0 | 0 | |||
| 11 | | L. Tomlinson | 1 | 187 | 9/28/2003 | @ | 28 | 6.7 | 1 | 24 | 7 | 8 | 3.4 | 0 | ||
| 12 | | L. Tomlinson | 1 | 184 | 11/27/2005 | @ | 25 | 7.4 | 3 | 29 | 6 | 9 | 4.8 | 0 | ||
| 13 | | L. Tomlinson | 1 | 183 | 10/29/2006 | vs | 25 | 7.3 | 2 | 57 | 3 | 3 | 19.0 | 1 | ||
| 14 | | J. Fazande | 1 | 183 | 1/2/2000 | @ | 30 | 6.1 | 1 | 0 | 0 | 0 | 0 | |||
| 15 | | P. Lowe | 1 | 183 | 12/22/1963 | vs | 17 | 10.8 | 2 | 12 | 1 | 12.0 | 0 | |||
| 16 | | G. Brown | 1 | 181 | 10/5/1997 | @ | 36 | 5.0 | 1 | 9 | 1 | 9.0 | 0 | |||
| 17 | | L. Tomlinson | 1 | 178 | 12/3/2006 | @ | 28 | 6.4 | 2 | 14 | 3 | 5 | 4.7 | 0 | ||
| 18 | | L. Tomlinson | 1 | 177 | 12/2/2007 | @ | 23 | 7.7 | 2 | 20 | 3 | 4 | 6.7 | 0 | ||
| 19 | | M. Butts | 1 | 176 | 12/17/1989 | @ | 39 | 4.5 | 0 | 0 | 0 | 0 | ||||
| 20 |  | A. Ekeler | 1 | 173 | 10/9/2022 | @ | 16 | 10.8 | 1 | 26 | 4 | 4 | 6.5 | 1 | ||
| 21 | | L. Tomlinson | 1 | 172 | 11/5/2006 | vs | 18 | 9.6 | 3 | 20 | 3 | 3 | 6.7 | 0 | ||
| 22 | | G. Anderson | 1 | 170 | 12/11/1988 | vs | 26 | 6.5 | 0 | 20 | 5 | 4.0 | 0 | |||
| 23 | | G. Brown | 1 | 169 | 10/26/1997 | vs | 28 | 6.0 | 1 | 15 | 1 | 15.0 | 0 | |||
| 24 | | K. Lincoln | 1 | 166 | 9/30/1962 | @ | 12 | 13.8 | 1 | 29 | 1 | 29.0 | 0 | |||
| 25 | | N. Means | 1 | 165 | 9/20/1998 | @ | 22 | 7.5 | 1 | 0 | 0 | 0 | ||||
WAS
STLResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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3,727
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RUSH
643
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REC
789
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Team Rankings
PPG
21.6
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20.0
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RUSH YDS/G
121.6
12th
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232.5
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |