Clyde Edwards-Helaire had his most rushing yards in a game against the Bills on October 19, 2020, with 161 yards.

Interpreted as:

clyde edward helaire most rushing yards in regular-season game

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	Clyde Edwards-Helaire C. Edwards-Helaire	161	10/19/2020	KC	@	BUF	26	6.2	0	8	4	4	2.0	0
2	Clyde Edwards-Helaire C. Edwards-Helaire	138	9/10/2020	KC	vs	HOU	25	5.5	1	0	0	2		0
3	Clyde Edwards-Helaire C. Edwards-Helaire	102	10/3/2021	KC	@	PHI	14	7.3	0	12	2	3	6.0	1
4	Clyde Edwards-Helaire C. Edwards-Helaire	100	9/26/2021	KC	vs	LAC	17	5.9	0	9	2	2	4.5	1
5	Clyde Edwards-Helaire C. Edwards-Helaire	92	10/2/2022	KC	@	TB	19	4.8	1	2	1	2	2.0	1
6	Clyde Edwards-Helaire C. Edwards-Helaire	79	12/20/2020	KC	@	NO	14	5.6	0	4	1	2	4.0	0
7	Clyde Edwards-Helaire C. Edwards-Helaire	74	9/15/2022	KC	vs	LAC	8	9.3	0	44	4	4	11.0	0
8	Clyde Edwards-Helaire C. Edwards-Helaire	69	11/22/2020	KC	@	LV	14	4.9	2	8	1	2	8.0	0
9	Clyde Edwards-Helaire C. Edwards-Helaire	64	10/5/2020	KC	vs	NE	16	4.0	0	27	3	3	9.0	0
10	Clyde Edwards-Helaire C. Edwards-Helaire	64	9/28/2020	KC	@	BAL	20	3.2	0	70	5	6	14.0	0
11	Clyde Edwards-Helaire C. Edwards-Helaire	63	11/21/2021	KC	vs	DAL	12	5.3	1	13	2	2	6.5	0
12	Clyde Edwards-Helaire C. Edwards-Helaire	55	9/24/2023	KC	vs	CHI	15	3.7	1	2	1	1	2.0	0
13	Clyde Edwards-Helaire C. Edwards-Helaire	54	12/5/2021	KC	vs	DEN	14	3.9	0	28	3	3	9.3	0
14	Clyde Edwards-Helaire C. Edwards-Helaire	46	9/19/2021	KC	@	BAL	13	3.5	0	0	0	0		0
15	Clyde Edwards-Helaire C. Edwards-Helaire	46	10/25/2020	KC	@	DEN	8	5.8	1	17	1	4	17.0	0
16	Clyde Edwards-Helaire C. Edwards-Helaire	43	9/12/2021	KC	vs	CLE	14	3.1	0	29	3	3	9.7	0
17	Clyde Edwards-Helaire C. Edwards-Helaire	42	9/11/2022	KC	@	ARI	7	6.0	0	32	3	3	10.7	2
18	Clyde Edwards-Helaire C. Edwards-Helaire	40	10/11/2020	KC	vs	LV	10	4.0	0	40	3	8	13.3	0
19	Clyde Edwards-Helaire C. Edwards-Helaire	39	12/10/2023	KC	vs	BUF	11	3.5	0	29	2	4	14.5	0
20	Clyde Edwards-Helaire C. Edwards-Helaire	38	9/20/2020	KC	@	LAC	10	3.8	0	32	6	8	5.3	0
21	Clyde Edwards-Helaire C. Edwards-Helaire	37	12/17/2023	KC	@	NE	13	2.8	0	64	4	4	16.0	1
22	Clyde Edwards-Helaire C. Edwards-Helaire	37	12/12/2021	KC	vs	LV	10	3.7	2	5	3	3	1.7	0
23	Clyde Edwards-Helaire C. Edwards-Helaire	37	11/29/2020	KC	@	TB	11	3.4	0	2	1	1	2.0	0
24	Clyde Edwards-Helaire C. Edwards-Helaire	33	10/16/2022	KC	vs	BUF	9	3.7	0	0	0	0		0
25	Clyde Edwards-Helaire C. Edwards-Helaire	32	10/23/2022	KC	@	SF	6	5.3	1	0	0	1		0

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Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.

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Clyde Edwards-Helaire had his most rushing yards in a game against the Bills on October 19, 2020, with 161 yards.

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