Derrick Henry got his most total touchdowns in a game versus the Jaguars on December 6, 2018, with 4 touchdowns.

Interpreted as:

Derrick Henry most tds in a single regular-season game

	NAME	TD	DATE	TM		OPP	RUSH TD	REC TD	RET TD	FGM	XPM	XP2	SFTY	PTS
1	Derrick Henry D. Henry	4	12/6/2018	TEN	vs	JAX	4	0	0	0	0	0	0	24
2	Derrick Henry D. Henry	3	10/18/2021	TEN	vs	BUF	3	0	0	0	0	0	0	18
3	Derrick Henry D. Henry	3	10/10/2021	TEN	@	JAX	3	0	0	0	0	0	0	18
4	Derrick Henry D. Henry	3	9/19/2021	TEN	@	SEA	3	0	0	0	0	0	0	18
5	Derrick Henry D. Henry	3	11/29/2020	TEN	@	IND	3	0	0	0	0	0	0	18
6	Derrick Henry D. Henry	3	12/29/2019	TEN	@	HOU	3	0	0	0	0	0	0	18
7	Derrick Henry D. Henry	2	9/7/2025	BAL	@	BUF	2	0	0	0	0	0	0	12
8	Derrick Henry D. Henry	2	1/4/2025	BAL	vs	CLE	2	0	0	0	0	0	0	12
9	Derrick Henry D. Henry	2	11/3/2024	BAL	vs	DEN	2	0	0	0	0	0	0	12
10	Derrick Henry D. Henry	2	10/13/2024	BAL	vs	WAS	2	0	0	0	0	0	0	12
11	Derrick Henry D. Henry	2	9/29/2024	BAL	vs	BUF	1	1	0	0	0	0	0	12
12	Derrick Henry D. Henry	2	9/22/2024	BAL	@	DAL	2	0	0	0	0	0	0	12
13	Derrick Henry D. Henry	2	12/11/2023	TEN	@	MIA	2	0	0	0	0	0	0	12
14	Derrick Henry D. Henry	2	12/3/2023	TEN	vs	IND	2	0	0	0	0	0	0	12
15	Derrick Henry D. Henry	2	11/26/2023	TEN	vs	CAR	2	0	0	0	0	0	0	12
16	Derrick Henry D. Henry	2	11/6/2022	TEN	@	KC	2	0	0	0	0	0	0	12
17	Derrick Henry D. Henry	2	10/30/2022	TEN	@	HOU	2	0	0	0	0	0	0	12
18	Derrick Henry D. Henry	2	10/9/2022	TEN	@	WAS	2	0	0	0	0	0	0	12
19	Derrick Henry D. Henry	2	1/3/2021	TEN	@	HOU	2	0	0	0	0	0	0	12
20	Derrick Henry D. Henry	2	12/13/2020	TEN	@	JAX	2	0	0	0	0	0	0	12
21	Derrick Henry D. Henry	2	10/18/2020	TEN	vs	HOU	2	0	0	0	0	0	0	12
22	Derrick Henry D. Henry	2	10/13/2020	TEN	vs	BUF	2	0	0	0	0	0	0	12
23	Derrick Henry D. Henry	2	9/27/2020	TEN	@	MIN	2	0	0	0	0	0	0	12
24	Derrick Henry D. Henry	2	12/8/2019	TEN	@	OAK	2	0	0	0	0	0	0	12
25	Derrick Henry D. Henry	2	11/24/2019	TEN	vs	JAX	2	0	0	0	0	0	0	12

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Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.

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Wed 9/3	DAL	@	PHI	20-24
Thu 9/4	KC	@	LAC	21-27
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Sat 9/6	TB	@	ATL	23-20
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Thu 10/9	PHI	@	NYG	8:15 PM
Sun 10/12	DEN	@	NYJ	9:30 AM
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Derrick Henry got his most total touchdowns in a game versus the Jaguars on December 6, 2018, with 4 touchdowns.

Interpreted as:

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