O.J. Simpson has the most career rushing yards per game by a Bills running back, with 90.9 per game.
Interpreted as:
highest rb career rushing yards per game from buf drafted in the first 2 rounds| NAME | RUSH YDS/G | GP | RUSH YDS | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 90.9 | 112 | 10,183 | 2,123 | 4.8 | 57 | 1,924 | 175 | 11.0 | 17.2 | 12 | |
| 2 |  | W. McGahee | 73.2 | 46 | 3,365 | 868 | 3.9 | 24 | 503 | 68 | 101 | 7.4 | 10.9 | 0 |
| 3 | | C. Gilchrist | 72.8 | 42 | 3,056 | 676 | 4.5 | 31 | 875 | 78 | 11.2 | 20.8 | 4 | |
| 4 | | T. Henry | 71.3 | 54 | 3,849 | 963 | 4.0 | 27 | 691 | 103 | 140 | 6.7 | 12.8 | 2 |
| 5 | | J. Cribbs | 69.5 | 64 | 4,445 | 1,082 | 4.1 | 21 | 1,783 | 180 | 9.9 | 27.9 | 15 | |
| 6 | | T. Thomas | 69.0 | 173 | 11,938 | 2,849 | 4.2 | 65 | 4,341 | 456 | 5 | 9.5 | 25.1 | 22 |
| 7 |  | L. McCoy | 66.9 | 57 | 3,814 | 885 | 4.3 | 25 | 1,334 | 175 | 230 | 7.6 | 23.4 | 5 |
| 8 |  | J. Cook III | 64.5 | 66 | 4,259 | 842 | 5.1 | 32 | 1,174 | 130 | 164 | 9.0 | 17.8 | 9 |
| 9 | | A. Williams | 63.0 | 1 | 63 | 12 | 5.3 | 2 | 20 | 1 | 1 | 20.0 | 20.0 | 0 |
| 10 |  | M. Lynch | 61.4 | 45 | 2,765 | 687 | 4.0 | 17 | 670 | 94 | 131 | 7.1 | 14.9 | 1 |
| 11 | | G. Bell | 60.5 | 40 | 2,420 | 589 | 4.1 | 19 | 1,032 | 108 | 9.6 | 25.8 | 4 | |
| 12 | | F. Jackson | 53.3 | 106 | 5,646 | 1,279 | 4.4 | 30 | 2,640 | 322 | 437 | 8.2 | 24.9 | 7 |
| 13 |  | D. Singletary | 51.7 | 61 | 3,151 | 672 | 4.7 | 16 | 971 | 145 | 193 | 6.7 | 15.9 | 4 |
| 14 | | A. Smith | 51.4 | 57 | 2,932 | 760 | 3.9 | 26 | 240 | 38 | 7 | 6.3 | 4.2 | 0 |
| 15 | | C.J. Spiller | 47.4 | 70 | 3,321 | 668 | 5.0 | 12 | 1,195 | 158 | 202 | 7.6 | 17.1 | 6 |
| 16 | | B. Gregory | 47.2 | 6 | 283 | 52 | 5.4 | 1 | 21 | 5 | 4.2 | 3.5 | 0 | |
| 17 | | K. Williams | 47.0 | 11 | 517 | 93 | 5.6 | 7 | 96 | 11 | 14 | 8.7 | 8.7 | 2 |
| 18 | | R. Kochman | 46.4 | 5 | 232 | 47 | 4.9 | 0 | 148 | 4 | 37.0 | 29.6 | 1 | |
| 19 | | M. Gillislee | 42.2 | 20 | 844 | 148 | 5.7 | 11 | 79 | 15 | 18 | 5.3 | 4.0 | 1 |
| 20 | | J. Kinney | 39.6 | 12 | 475 | 116 | 4.1 | 1 | 78 | 14 | 5.6 | 6.5 | 0 | |
| 21 | | K. Ford | 39.5 | 2 | 79 | 21 | 3.8 | 0 | 21 | 3 | 5 | 7.0 | 10.5 | 0 |
| 22 | | B. Burnett | 39.2 | 22 | 862 | 232 | 3.7 | 4 | 533 | 45 | 11.8 | 24.2 | 4 | |
| 23 | | W. Carlton | 38.7 | 87 | 3,368 | 819 | 4.1 | 29 | 1,329 | 110 | 12.1 | 15.3 | 5 | |
| 24 | | K. Lincoln | 38.1 | 18 | 685 | 185 | 3.7 | 4 | 561 | 42 | 13.4 | 31.2 | 5 | |
| 25 |  | F. Gore | 37.4 | 16 | 599 | 166 | 3.6 | 2 | 100 | 13 | 16 | 7.7 | 6.3 | 0 |
StatMuse has season-level data for rushing yards per game going back to the 1932 season.
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
