James Cook III had his most rushing yards in a game versus the Panthers on October 26, with 216 yards.

Interpreted as:

james cook most rushing yards in a regular-season game

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	James Cook III J. Cook III	216	10/26/2025	BUF	@	CAR	19	11.4	2	0	0	0		0
2	James Cook III J. Cook III	179	12/17/2023	BUF	vs	DAL	25	7.2	1	42	2	3	21.0	1
3	James Cook III J. Cook III	144	11/30/2025	BUF	@	PIT	32	4.5	0	33	3	3	11.0	0
4	James Cook III J. Cook III	132	9/14/2025	BUF	@	NYJ	21	6.3	2	3	1	1	3.0	0
5	James Cook III J. Cook III	123	9/17/2023	BUF	vs	LV	17	7.2	0	36	4	4	9.0	0
6	James Cook III J. Cook III	117	12/21/2025	BUF	@	CLE	16	7.3	2	17	1	2	17.0	0
7	James Cook III J. Cook III	117	9/28/2025	BUF	vs	NO	22	5.3	1	18	3	4	6.0	0
8	James Cook III J. Cook III	116	11/20/2025	BUF	@	HOU	17	6.8	1	13	3	3	4.3	0
9	James Cook III J. Cook III	114	11/2/2025	BUF	vs	KC	27	4.2	0	11	1	1	11.0	0
10	James Cook III J. Cook III	111	10/27/2024	BUF	@	SEA	17	6.5	2	22	3	3	7.3	0
11	James Cook III J. Cook III	109	11/13/2023	BUF	vs	DEN	12	9.1	0	11	2	2	5.5	0
12	James Cook III J. Cook III	108	9/18/2025	BUF	vs	MIA	19	5.7	1	10	3	3	3.3	0
13	James Cook III J. Cook III	107	12/14/2025	BUF	@	NE	22	4.9	2	4	2	3	2.0	1
14	James Cook III J. Cook III	107	12/1/2024	BUF	vs	SF	14	7.6	1	13	1	1	13.0	0
15	James Cook III J. Cook III	105	12/15/2024	BUF	@	DET	14	7.5	2	28	1	1	28.0	0
16	James Cook III J. Cook III	100	12/22/2024	BUF	vs	NE	11	9.1	1	26	3	3	8.7	1
17	James Cook III J. Cook III	99	12/24/2022	BUF	@	CHI	11	9.0	1	9	1	2	9.0	0
18	James Cook III J. Cook III	98	9/24/2023	BUF	@	WAS	15	6.5	0	14	2	3	7.0	0
19	James Cook III J. Cook III	87	10/13/2025	BUF	@	ATL	17	5.1	0	0	0	0		0
20	James Cook III J. Cook III	86	11/20/2022	BUF	vs	CLE	11	7.8	0	0	0	1		0
21	James Cook III J. Cook III	82	10/6/2024	BUF	@	HOU	20	4.1	1	17	2	3	8.5	0
22	James Cook III J. Cook III	80	12/7/2025	BUF	vs	CIN	18	4.4	0	31	2	2	15.5	0
23	James Cook III J. Cook III	80	11/10/2024	BUF	@	IND	19	4.2	1	5	1	3	5.0	0
24	James Cook III J. Cook III	78	9/12/2024	BUF	@	MIA	11	7.1	2	17	1	1	17.0	1
25	James Cook III J. Cook III	74	12/28/2025	BUF	vs	PHI	20	3.7	0	3	1	4	3.0	0

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AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
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Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
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Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
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Chargers - w	11	6	0	.647
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Buccaneers - e	8	9	0	.471
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Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176

James Cook III had his most rushing yards in a game versus the Panthers on October 26, with 216 yards.

Interpreted as:

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