James Cook III scored his most total touchdowns in a game against the Dolphins on September 12, 2024, with 3 touchdowns.
Interpreted as:
james cook most touchdowns in regular-season game| NAME | TD | DATE | TM | OPP | RUSH TD | REC TD | RET TD | FGM | XPM | XP2 | SFTY | PTS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 3 | 9/12/2024 |  BUF | @ |  MIA | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 18 |
| 2 | | J. Cook III | 2 | 9/14/2025 | BUF | @ |  NYJ | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 3 | | J. Cook III | 2 | 12/22/2024 | BUF | vs |  NE | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 12 |
| 4 | | J. Cook III | 2 | 12/15/2024 | BUF | @ |  DET | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 5 | | J. Cook III | 2 | 11/17/2024 | BUF | vs |  KC | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 6 | | J. Cook III | 2 | 10/27/2024 | BUF | @ |  SEA | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 7 | | J. Cook III | 2 | 12/17/2023 | BUF | vs |  DAL | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 12 |
| 8 | | J. Cook III | 1 | 9/28/2025 | BUF | vs |  NO | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 9 | | J. Cook III | 1 | 9/18/2025 | BUF | vs | MIA | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 10 | | J. Cook III | 1 | 9/7/2025 | BUF | vs |  BAL | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 11 | | J. Cook III | 1 | 1/5/2025 | BUF | @ | NE | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 12 | | J. Cook III | 1 | 12/29/2024 | BUF | vs | NYJ | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 13 | | J. Cook III | 1 | 12/1/2024 | BUF | vs |  SF | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 14 | | J. Cook III | 1 | 11/10/2024 | BUF | @ |  IND | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 15 | | J. Cook III | 1 | 10/20/2024 | BUF | vs |  TEN | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 16 | | J. Cook III | 1 | 10/6/2024 | BUF | @ |  HOU | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 17 | | J. Cook III | 1 | 9/23/2024 | BUF | vs |  JAX | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 18 | | J. Cook III | 1 | 12/10/2023 | BUF | @ | KC | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 19 | | J. Cook III | 1 | 11/19/2023 | BUF | vs |  NYJ | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 20 | | J. Cook III | 1 | 10/22/2023 | BUF | @ | NE | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 21 | | J. Cook III | 1 | 10/1/2023 | BUF | vs | MIA | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 22 | | J. Cook III | 1 | 12/24/2022 | BUF | @ |  CHI | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 23 | | J. Cook III | 1 | 12/17/2022 | BUF | vs | MIA | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 24 | | J. Cook III | 1 | 10/9/2022 | BUF | vs |  PIT | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.
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