James Cook III rushed for his most yards in a regular-season or postseason game versus the Panthers on October 26, with 216 yards.
Interpreted as:
james cook most rushing yds in a game including playoffs| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 216 | 10/26/2025 | @ | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 2 | | J. Cook III | 179 | 12/17/2023 | vs | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 | ||
| 3 | | J. Cook III | 144 | 11/30/2025 | @ | 32 | 4.5 | 0 | 33 | 3 | 3 | 11.0 | 0 | ||
| 4 | | J. Cook III | 132 | 9/14/2025 | @ | 21 | 6.3 | 2 | 3 | 1 | 1 | 3.0 | 0 | ||
| 5 | | J. Cook III | 123 | 9/17/2023 | vs | 17 | 7.2 | 0 | 36 | 4 | 4 | 9.0 | 0 | ||
| 6 | | J. Cook III | 120 | 1/12/2025 | vs | 23 | 5.2 | 1 | 0 | 0 | 0 | 0 | |||
| 7 | | J. Cook III | 117 | 1/17/2026 | @ | 24 | 4.9 | 0 | 24 | 2 | 3 | 12.0 | 0 | ||
| 8 | | J. Cook III | 117 | 12/21/2025 | @ | 16 | 7.3 | 2 | 17 | 1 | 2 | 17.0 | 0 | ||
| 9 | | J. Cook III | 117 | 9/28/2025 | vs | 22 | 5.3 | 1 | 18 | 3 | 4 | 6.0 | 0 | ||
| 10 | | J. Cook III | 116 | 11/20/2025 | @ | 17 | 6.8 | 1 | 13 | 3 | 3 | 4.3 | 0 | ||
| 11 | | J. Cook III | 114 | 11/2/2025 | vs | 27 | 4.2 | 0 | 11 | 1 | 1 | 11.0 | 0 | ||
| 12 | | J. Cook III | 111 | 10/27/2024 | @ | 17 | 6.5 | 2 | 22 | 3 | 3 | 7.3 | 0 | ||
| 13 | | J. Cook III | 109 | 11/13/2023 | vs | 12 | 9.1 | 0 | 11 | 2 | 2 | 5.5 | 0 | ||
| 14 | | J. Cook III | 108 | 9/18/2025 | vs | 19 | 5.7 | 1 | 10 | 3 | 3 | 3.3 | 0 | ||
| 15 | | J. Cook III | 107 | 12/14/2025 | @ | 22 | 4.9 | 2 | 4 | 2 | 3 | 2.0 | 1 | ||
| 16 | | J. Cook III | 107 | 12/1/2024 | vs | 14 | 7.6 | 1 | 13 | 1 | 1 | 13.0 | 0 | ||
| 17 | | J. Cook III | 105 | 12/15/2024 | @ | 14 | 7.5 | 2 | 28 | 1 | 1 | 28.0 | 0 | ||
| 18 | | J. Cook III | 100 | 12/22/2024 | vs | 11 | 9.1 | 1 | 26 | 3 | 3 | 8.7 | 1 | ||
| 19 | | J. Cook III | 99 | 12/24/2022 | @ | 11 | 9.0 | 1 | 9 | 1 | 2 | 9.0 | 0 | ||
| 20 | | J. Cook III | 98 | 9/24/2023 | @ | 15 | 6.5 | 0 | 14 | 2 | 3 | 7.0 | 0 | ||
| 21 | | J. Cook III | 87 | 10/13/2025 | @ | 17 | 5.1 | 0 | 0 | 0 | 0 | 0 | |||
| 22 | | J. Cook III | 86 | 11/20/2022 | vs | 11 | 7.8 | 0 | 0 | 0 | 1 | 0 | |||
| 23 | | J. Cook III | 85 | 1/26/2025 | @ | 13 | 6.5 | 2 | 49 | 3 | 3 | 16.3 | 0 | ||
| 24 | | J. Cook III | 82 | 10/6/2024 | @ | 20 | 4.1 | 1 | 17 | 2 | 3 | 8.5 | 0 | ||
| 25 | | J. Cook III | 80 | 12/7/2025 | vs | 18 | 4.4 | 0 | 31 | 2 | 2 | 15.5 | 0 | ||
CHIResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |