The Dallas Cowboys had the highest point differential by a team in a game in 2021, with a 42-point differential versus the Washington Football Team on December 26.

largest margin of victory game 2021 nfl
Interpreted as:
largest margin of victory regular-season game 2021 NFL
12/26/2021Cowboys10/24/2021Patriots1/2/2022Patriots11/14/2021Cowboys10/3/2021Bills12/12/2021Chiefs11/14/2021Patriots10/31/2021Eagles10/24/2021Buccaneers9/19/2021Bills9/12/2021Saints1/2/2022Titans12/5/2021Colts11/28/2021Bengals12/5/2021Rams12/12/2021Broncos11/14/2021Bills10/17/2021Ravens10/17/2021Colts10/10/2021Buccaneers1/2/2022Packers11/14/2021Chiefs42414040403938383535353131313028282828282727
TEAMDATETMOPPRESULTDIFFTD1DWNOFFOPP OFF3DWN%4DWN%
Dallas CowboysDallas Cowboys12/26/2021
DALDAL
vs
WASWAS
W
56-14
4282849725766.7100.0
New England PatriotsNew England Patriots10/24/2021
NENE
vs
NYJNYJ
W
54-13
4173255129958.3100.0
New England PatriotsNew England Patriots1/2/2022
NENE
vs
JAXJAX
W
50-10
4073247125380.0
Dallas CowboysDallas Cowboys11/14/2021
DALDAL
vs
ATLATL
W
43-3
4062243121442.9100.0
Buffalo BillsBuffalo Bills10/3/2021
BUFBUF
vs
HOUHOU
W
40-0
4042645010941.750.0
Kansas City ChiefsKansas City Chiefs12/12/2021
KCKC
vs
LVLV
W
48-9
3962137229069.2
New England PatriotsNew England Patriots11/14/2021
NENE
vs
CLECLE
W
45-7
3863045221777.8
Philadelphia EaglesPhiladelphia Eagles10/31/2021
PHIPHI
@
DETDET
W
44-6
3852735022850.0
Tampa Bay BuccaneersTampa Bay Buccaneers10/24/2021
TBTB
vs
CHICHI
W
38-3
3552840831133.350.0
Buffalo BillsBuffalo Bills9/19/2021
BUFBUF
@
MIAMIA
W
35-0
3552131421653.8100.0
New Orleans SaintsNew Orleans Saints9/12/2021
NONO
vs
GBGB
W
38-3
3552232222950.0100.0
Tennessee TitansTennessee Titans1/2/2022
TENTEN
vs
MIAMIA
W
34-3
3141730825646.7100.0
Indianapolis ColtsIndianapolis Colts12/5/2021
INDIND
@
HOUHOU
W
31-0
3142638914153.8100.0
Cincinnati BengalsCincinnati Bengals11/28/2021
CINCIN
vs
PITPIT
W
41-10
3152537030145.5100.0
Los Angeles RamsLos Angeles Rams12/5/2021
LARLAR
vs
JAXJAX
W
37-7
3042441819741.7100.0
Denver BroncosDenver Broncos12/12/2021
DENDEN
vs
DETDET
W
38-10
2852535831666.7100.0
Buffalo BillsBuffalo Bills11/14/2021
BUFBUF
@
NYJNYJ
W
45-17
2862648936657.1
Baltimore RavensBaltimore Ravens10/17/2021
BALBAL
vs
LACLAC
W
34-6
2842732720854.5
Indianapolis ColtsIndianapolis Colts10/17/2021
INDIND
vs
HOUHOU
W
31-3
2841538835330.0100.0
Tampa Bay BuccaneersTampa Bay Buccaneers10/10/2021
TBTB
vs
MIAMIA
W
45-17
2863355830172.7
Green Bay PackersGreen Bay Packers1/2/2022
GBGB
vs
MINMIN
W
37-10
2742948120653.80.0
Kansas City ChiefsKansas City Chiefs11/14/2021
KCKC
@
LVLV
W
41-14
2752951629960.0100.0
Los Angeles RamsLos Angeles Rams10/17/2021
LARLAR
@
NYGNYG
W
38-11
2752236526118.2100.0
Chicago BearsChicago Bears1/2/2022
CHICHI
vs
NYGNYG
W
29-3
2631724915537.566.7
Tampa Bay BuccaneersTampa Bay Buccaneers12/26/2021
TBTB
@
CARCAR
W
32-6
2632139127350.0
Kansas City ChiefsKansas City Chiefs12/26/2021
KCKC
vs
PITPIT
W
36-10
2642538130336.4100.0
Indianapolis ColtsIndianapolis Colts11/21/2021
INDIND
@
BUFBUF
W
41-15
2652837031166.70.0
Arizona CardinalsArizona Cardinals10/24/2021
ARIARI
vs
HOUHOU
W
31-5
2642439716050.0100.0
Denver BroncosDenver Broncos9/26/2021
DENDEN
vs
NYJNYJ
W
26-0
2622334316236.4
Philadelphia EaglesPhiladelphia Eagles9/12/2021
PHIPHI
@
ATLATL
W
32-6
2642443426046.20.0
Dallas CowboysDallas Cowboys1/8/2022
DALDAL
@
PHIPHI
W
51-26
2572247531561.5100.0
Buffalo BillsBuffalo Bills11/25/2021
BUFBUF
@
NONO
W
31-6
2542136119061.5100.0