Since 2020, the Buffalo Bills have their lowest point differential in a game on November 21, 2021 and on October 13, 2020, with a -26-point differential.
Interpreted as:
lowest point differential in a regular-season game by bills since 2020| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | -26 | 11/21/2021 | vs | L 15-41 | 2 | 19 | 311 | 370 | 50.0 | |||
| 2 | | Bills | -26 | 10/13/2020 | @ | L 16-42 | 2 | 23 | 370 | 334 | 76.5 | |||
| 3 | | Bills | -25 | 9/29/2024 | @ | L 10-35 | 1 | 12 | 236 | 427 | 23.1 | 100.0 | ||
| 4 | | Bills | -17 | 11/9/2025 | @ | L 13-30 | 2 | 20 | 376 | 370 | 33.3 | 50.0 | ||
| 5 | | Bills | -10 | 10/13/2025 | @ | L 14-24 | 2 | 17 | 291 | 443 | 22.2 | 0.0 | ||
| 6 | | Bills | -9 | 10/19/2020 | vs | L 17-26 | 2 | 20 | 206 | 466 | 44.4 | |||
| 7 | | Bills | -7 | 1/5/2025 | @ | L 16-23 | 2 | 16 | 259 | 309 | 40.0 | 25.0 | ||
| 8 | | Bills | -7 | 9/12/2021 | vs | L 16-23 | 1 | 22 | 371 | 252 | 44.4 | 33.3 | ||
| 9 | | Bills | -6 | 11/5/2023 | @ | L 18-24 | 2 | 21 | 317 | 397 | 58.3 | |||
| 10 | | Bills | -6 | 9/11/2023 | @ | L 16-22 | 1 | 19 | 314 | 289 | 38.5 | |||
| 11 | | Bills | -6 | 12/12/2021 | @ | L 27-33 | 3 | 27 | 466 | 488 | 15.4 | 66.7 | ||
| 12 | | Bills | -5 | 10/8/2023 | vs | L 20-25 | 3 | 18 | 388 | 474 | 41.7 | |||
| 13 | | Bills | -4 | 11/20/2025 | @ | L 19-23 | 2 | 14 | 326 | 261 | 31.3 | 60.0 | ||
| 14 | | Bills | -4 | 10/22/2023 | @ | L 25-29 | 3 | 24 | 339 | 364 | 41.7 | 66.7 | ||
| 15 | | Bills | -4 | 12/6/2021 | vs | L 10-14 | 1 | 16 | 230 | 241 | 30.8 | 0.0 | ||
| 16 | | Bills | -3 | 10/5/2025 | vs | L 20-23 | 2 | 25 | 363 | 338 | 55.6 | |||
| 17 | | Bills | -3 | 10/6/2024 | @ | L 20-23 | 2 | 16 | 276 | 425 | 21.4 | 100.0 | ||
| 18 | | Bills | -3 | 11/26/2023 | @ | L 34-37 | 4 | 29 | 505 | 378 | 59.1 | 100.0 | ||
| 19 | | Bills | -3 | 11/13/2022 | vs | L 30-33 | 3 | 29 | 486 | 481 | 53.8 | 0.0 | ||
| 20 | | Bills | -3 | 11/6/2022 | @ | L 17-20 | 2 | 19 | 317 | 310 | 61.5 | 0.0 | ||
| 21 | | Bills | -3 | 11/7/2021 | @ | L 6-9 | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 22 | | Bills | -3 | 10/18/2021 | @ | L 31-34 | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 23 | | Bills | -2 | 12/8/2024 | @ | L 42-44 | 6 | 25 | 445 | 457 | 55.6 | |||
| 24 | | Bills | -2 | 11/13/2023 | vs | L 22-24 | 3 | 18 | 369 | 300 | 37.5 | 0.0 | ||
| 25 | | Bills | -2 | 9/25/2022 | @ | L 19-21 | 2 | 31 | 497 | 212 | 61.1 | 66.7 | ||
NYJMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
