Marcus Mariota had his most rushing yards per attempt in a game against the Ravens on September 13, 2021, with 31.0 per attempt.

marcus mariota most rushing yards per attempt in a game
Interpreted as:
Marcus Mariota most rushing yards per attempt in a regular-season game
9/13/2021Mariota11/10/2022Mariota10/14/2018Mariota12/6/2015Mariota11/27/2016Mariota12/2/2018Mariota11/11/2018Mariota12/17/2020Mariota10/1/2017Mariota10/11/2015Mariota10/16/2016Mariota10/9/2022Mariota9/10/2017Mariota10/9/2016Mariota11/12/2017Mariota10/16/2022Mariota11/27/2022Mariota9/8/2019Mariota12/24/2017Mariota10/22/2017Mariota12/3/2017Mariota9/29/2019Mariota31.014.312.512.411.510.810.59.89.89.49.18.78.78.68.58.38.28.08.08.07.77.3
Results may be incomplete. StatMuse has complete game-level data for rushing yards per attempt going back to the 1960 season.