Matthew Stafford has a 1-3 record with the Lions in the regular-season and playoffs versus the 49ers in his career.
| NAME | DATE | REC | TM | OPP | W% | CMP | ATT | PCT | YDS | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Stafford | 10/16/2011 | 0-1 | vs | .000 | 28 | 50 | 56.0 | 293 | 5.9 | 2 | 0 | 86.5 | 4.0 | 0.0 | 5 | 49 | ||
| 2 | | M. Stafford | 9/16/2012 | 0-1 | @ | .000 | 19 | 32 | 59.4 | 230 | 7.2 | 1 | 1 | 78.9 | 3.1 | 3.1 | 2 | 16 | ||
| 3 | | M. Stafford | 12/27/2015 | 1-0 | vs | 1.000 | 29 | 37 | 78.4 | 301 | 8.1 | 2 | 0 | 118.6 | 5.4 | 0.0 | 2 | 17 | ||
| 4 | | M. Stafford | 9/16/2018 | 0-1 | @ | .000 | 34 | 53 | 64.2 | 347 | 6.5 | 3 | 0 | 101.7 | 5.7 | 0.0 | 2 | 18 | ||
| Average | .250 | 27.5 | 43.0 | 64.0 | 292.8 | 6.8 | 2.0 | 0.3 | 96.8 | 4.7 | 0.6 | 2.8 | 25.0 | |||||||
| Total | 1-3 | .250 | 110 | 172 | 64.0 | 1,171 | 6.8 | 8 | 1 | 96.8 | 4.7 | 0.6 | 11 | 100 |
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |