Barry Sanders had the most games with 110+ rushing yards, with 60 games.

Interpreted as:

most 110 or more yard rush regular-season games by a player

	NAME	GP	RUSH YDS	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Barry Sanders B. Sanders	60	8,962	1,404	6.4	149.4	60	1,095	137		8.0	18.3	4
2	Emmitt Smith E. Smith	58	7,885	1,468	5.4	135.9	64	1,025	173	28	5.9	17.7	6
3	Walter Payton W. Payton	56	8,056	1,449	5.6	143.9	53	1,174	130		9.0	21.0	5
4	Eric Dickerson E. Dickerson	50	7,344	1,350	5.4	146.9	53	719	94		7.6	14.4	2
5	Curtis Martin C. Martin	46	6,230	1,221	5.1	135.4	44	970	129	113	7.5	21.1	5
6	Adrian Peterson A. Peterson	44	6,780	1,105	6.1	154.1	54	547	71	105	7.7	12.4	2
7	Derrick Henry D. Henry	43	6,669	1,050	6.4	155.1	64	499	62	78	8.0	11.6	2
8	Jerome Bettis J. Bettis	42	5,511	1,111	5.0	131.2	26	334	48	19	7.0	8.0	0
9	Edgerrin James E. James	38	4,990	1,023	4.9	131.3	37	999	125	161	8.0	26.3	4
10	O.J. Simpson	37	5,727	950	6.0	154.8	32	437	44		9.9	11.8	4
11	LeSean McCoy L. McCoy	36	4,846	785	6.2	134.6	31	522	92	110	5.7	14.5	3
12	Fred Taylor F. Taylor	36	5,010	846	5.9	139.2	34	723	77	85	9.4	20.1	1
13	LaDainian Tomlinson L. Tomlinson	35	5,440	903	6.0	155.4	56	754	134	177	5.6	21.5	4
14	Jim Brown J. Brown	35	5,260	794	6.6	150.3	42	1,020	84		12.1	29.1	10
15	Chris Johnson C. Johnson	34	4,764	774	6.2	140.1	42	731	89	119	8.2	21.5	2
16	Clinton Portis C. Portis	34	4,833	890	5.4	142.1	37	641	66	91	9.7	18.9	2
17	Thurman Thomas T. Thomas	33	4,309	848	5.1	130.6	23	804	82		9.8	24.4	6
18	Tony Dorsett T. Dorsett	33	4,505	735	6.1	136.5	28	741	64		11.6	22.5	3
19	Tiki Barber T. Barber	32	4,522	712	6.4	141.3	17	1,011	123	157	8.2	31.6	3
20	Shaun Alexander S. Alexander	31	4,584	818	5.6	147.9	54	369	49	76	7.5	11.9	5
21	Jamal Lewis J. Lewis	30	4,408	787	5.6	146.9	24	412	52	70	7.9	13.7	1
22	Corey Dillon C. Dillon	30	4,330	758	5.7	144.3	27	342	48	58	7.1	11.4	3
23	Marshall Faulk M. Faulk	30	4,460	696	6.4	148.7	39	1,314	134	128	9.8	43.8	7
24	Frank Gore F. Gore	29	4,025	666	6.0	138.8	19	640	73	103	8.8	22.1	3
25	Earl Campbell E. Campbell	29	4,538	864	5.3	156.5	39	150	26		5.8	5.2	0

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StatMuse has game-level data for rushing yards going back to the 1960 season.

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Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
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Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
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Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
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Packers - w	9	7	1	.559
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Rams - w	12	5	0	.706
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