Between the 2019 and 2022 seasons, Nick Chubb had the most games with 50+ rushing yards, with 52 games.

Interpreted as:

most 50 or more yard rushing regular-season games by a player 2019 to 2022

	NAME	GP	RUSH YDS	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Nick Chubb N. Chubb	52	5,119	937	5.5	98.4	39	711	85	111	8.4	13.7	2
2	Derrick Henry D. Henry	50	5,877	1,176	5.0	117.5	54	778	81	105	9.6	15.6	2
3	Josh Jacobs J. Jacobs	44	4,161	896	4.6	94.6	36	876	114	140	7.7	19.9	0
4	Dalvin Cook D. Cook	44	4,587	908	5.1	104.3	38	1,123	126	160	8.9	25.5	2
5	Lamar Jackson L. Jackson	41	3,395	494	6.9	82.8	16	0	0	0		0.0	0
6	Ezekiel Elliott E. Elliott	41	3,378	725	4.7	82.4	29	774	107	141	7.2	18.9	4
7	Jonathan Taylor J. Taylor	37	3,716	703	5.3	100.4	32	680	90	114	7.6	18.4	3
8	David Montgomery D. Montgomery	37	2,907	653	4.5	78.6	20	751	95	117	7.9	20.3	4
9	Alvin Kamara A. Kamara	37	2,919	619	4.7	78.9	20	1,550	182	231	8.5	41.9	10
10	Joe Mixon J. Mixon	36	3,130	719	4.4	86.9	24	765	101	120	7.6	21.3	6
11	Miles Sanders M. Sanders	36	3,044	542	5.6	84.6	19	616	79	116	7.8	17.1	2
12	Aaron Jones Sr. A. Jones Sr.	35	3,259	556	5.9	93.1	24	961	118	154	8.1	27.5	12
13	Saquon Barkley S. Barkley	30	2,618	547	4.8	87.3	17	809	112	155	7.2	27.0	4
14	Austin Ekeler A. Ekeler	29	2,122	407	5.2	73.2	25	1,259	133	153	9.5	43.4	12
15	Christian McCaffrey C. McCaffrey	29	2,691	528	5.1	92.8	24	1,759	198	234	8.9	60.7	8
16	Devin Singletary D. Singletary	28	2,158	404	5.3	77.1	12	480	67	88	7.2	17.1	2
17	Melvin Gordon M. Gordon	26	2,066	422	4.9	79.5	19	400	54	70	7.4	15.4	1
18	Jamaal Williams J. Williams	26	1,879	402	4.7	72.3	17	282	41	47	6.9	10.8	1
19	Leonard Fournette L. Fournette	26	2,193	470	4.7	84.3	15	861	119	154	7.2	33.1	3
20	James Conner J. Conner	23	1,815	393	4.6	78.9	17	503	66	75	7.6	21.9	4
21	Tony Pollard T. Pollard	22	1,812	272	6.7	82.4	14	417	48	61	8.7	19.0	2
22	Raheem Mostert R. Mostert	22	1,685	287	5.9	76.6	10	406	40	53	10.2	18.5	4
23	Chris Carson C. Carson	22	1,830	386	4.7	83.2	11	387	57	74	6.8	17.6	3
24	James Robinson J. Robinson	21	1,802	366	4.9	85.8	15	370	59	76	6.3	17.6	2
25	Najee Harris N. Harris	20	1,769	416	4.3	88.5	11	365	60	75	6.1	18.3	3

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StatMuse has game-level data for rushing yards going back to the 1960 season.

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Bills - w	11	5	0	.688
Dolphins - e	7	9	0	.438
Jets - e	3	13	0	.188
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Ravens	8	8	0	.500
Bengals - e	6	10	0	.375
Browns - e	4	12	0	.250
AFC South	W	L	T	PCT
Jaguars - x	12	4	0	.750
Texans - x	11	5	0	.688
Colts - e	8	8	0	.500
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Falcons - e	6	9	0	.400
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Rams - x	11	4	0	.733
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