I don't have anything for this season, but James Cook III had the most games with 75+ rushing yards in 2025, with 11 games.
Interpreted as:
most 75 or more rushing yard games by a player this season| NAME | GP | RUSH YDS | SEASON | TM | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 11 | 1,338 | 2025 | 230 | 5.8 | 121.6 | 11 | 140 | 19 | 22 | 7.4 | 12.7 | 1 | |
| 2 |  | B. Robinson | 10 | 1,168 | 2025 | 198 | 5.9 | 116.8 | 7 | 509 | 46 | 64 | 11.1 | 50.9 | 2 | |
| 3 |  | D. Henry | 10 | 1,252 | 2025 | 209 | 6.0 | 125.2 | 9 | 59 | 9 | 12 | 6.6 | 5.9 | 0 | |
| 4 |  | D. Achane | 9 | 993 | 2025 | 154 | 6.4 | 110.3 | 8 | 187 | 26 | 32 | 7.2 | 20.8 | 0 | |
| 5 |  | J. Taylor | 9 | 1,129 | 2025 | 186 | 6.1 | 125.4 | 12 | 251 | 28 | 32 | 9.0 | 27.9 | 2 | |
| 6 |  | J. Williams | 9 | 863 | 2025 | 155 | 5.6 | 95.9 | 5 | 84 | 20 | 26 | 4.2 | 9.3 | 1 | |
| 7 |  | K. Williams | 7 | 630 | 2025 | 111 | 5.7 | 90.0 | 5 | 101 | 12 | 15 | 8.4 | 14.4 | 1 | |
| 8 |  | J.K. Dobbins | 7 | 608 | 2025 | 108 | 5.6 | 86.9 | 3 | 34 | 8 | 10 | 4.3 | 4.9 | 0 | |
| 9 |  | C. McCaffrey | 6 | 662 | 2025 | 133 | 5.0 | 110.3 | 7 | 302 | 34 | 41 | 8.9 | 50.3 | 4 | |
| 10 |  | D. Swift | 6 | 625 | 2025 | 103 | 6.1 | 104.2 | 4 | 110 | 10 | 16 | 11.0 | 18.3 | 1 | |
| 11 |  | Q. Judkins | 6 | 536 | 2025 | 132 | 4.1 | 89.3 | 5 | 80 | 11 | 14 | 7.3 | 13.3 | 0 | |
| 12 |  | S. Barkley | 6 | 653 | 2025 | 125 | 5.2 | 108.8 | 5 | 51 | 9 | 16 | 5.7 | 8.5 | 1 | |
| 13 |  | J. Gibbs | 6 | 762 | 2025 | 93 | 8.2 | 127.0 | 8 | 206 | 25 | 29 | 8.2 | 34.3 | 3 | |
| 14 |  | J. Jacobs | 6 | 519 | 2025 | 117 | 4.4 | 86.5 | 7 | 155 | 16 | 17 | 9.7 | 25.8 | 0 | |
| 15 |  | B. Hall | 6 | 628 | 2025 | 100 | 6.3 | 104.7 | 3 | 184 | 16 | 22 | 11.5 | 30.7 | 1 | |
| 16 |  | C. Brown | 5 | 493 | 2025 | 85 | 5.8 | 98.6 | 2 | 118 | 20 | 26 | 5.9 | 23.6 | 0 | |
| 17 |  | T. Pollard | 5 | 544 | 2025 | 98 | 5.6 | 108.8 | 3 | 18 | 3 | 5 | 6.0 | 3.6 | 0 | |
| 18 |  | K. Walker III | 5 | 469 | 2025 | 69 | 6.8 | 93.8 | 2 | 142 | 10 | 11 | 14.2 | 28.4 | 0 | |
| 19 |  | T. Etienne Jr. | 5 | 513 | 2025 | 89 | 5.8 | 102.6 | 1 | 91 | 14 | 17 | 6.5 | 18.2 | 1 | |
| 20 |  | T. Henderson | 4 | 452 | 2025 | 57 | 7.9 | 113.0 | 4 | 16 | 3 | 4 | 5.3 | 4.0 | 0 | |
| 21 |  | K. Vidal | 4 | 462 | 2025 | 91 | 5.1 | 115.5 | 3 | 48 | 6 | 8 | 8.0 | 12.0 | 1 | |
| 22 |  | R. Dowdle | 4 | 598 | 2025 | 95 | 6.3 | 149.5 | 3 | 112 | 10 | 14 | 11.2 | 28.0 | 1 | |
| 23 |  | A. Jeanty | 4 | 428 | 2025 | 94 | 4.6 | 107.0 | 3 | 95 | 8 | 13 | 11.9 | 23.8 | 3 | |
| 24 |  | J. Croskey-Merritt | 4 | 394 | 2025 | 53 | 7.4 | 98.5 | 6 | 39 | 2 | 3 | 19.5 | 9.8 | 0 | |
| 25 |  | A. Jones Sr. | 3 | 239 | 2025 | 44 | 5.4 | 79.7 | 0 | 28 | 4 | 6 | 7.0 | 9.3 | 0 | |
StatMuse has game-level data for rushing yards going back to the 1960 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |