The Buffalo Bills made their most tackles in a game against the Steelers on November 28, 2010, with 74 tackles.

Interpreted as:

most buffalo bills tackles in a regular-season game

	TEAM	TKL	DATE	TM		OPP	RESULT	AST	COMB	SCK	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Bills	74	11/28/2010	BUF	vs	PIT	L 16-19	42	116	5.0	26	0	0	0	1	1	0
2	Bills	70	11/14/2004	BUF	@	NE	L 6-29	39	109	2.0	13	1	35	0	0	0	0
3	Bills	69	10/13/2013	BUF	vs	CIN	L 24-27	45	114	3.0	19	1	41	0	0	0	0
4	Bills	69	10/4/2009	BUF	@	MIA	L 10-38	8	77	6.0	29	0	0	0	3	0	0
5	Bills	68	12/1/2013	BUF	vs	ATL	L 31-34	33	101	6.0	39	0	0	0	0	1	0
6	Bills	68	10/5/2008	BUF	@	ARI	L 17-41	14	82	0.0	0	0	0	0	0	0	0
7	Bills	67	10/3/2010	BUF	vs	NYJ	L 14-38	40	107	0.0	0	0	0	0	0	0	0
8	Bills	67	11/1/2009	BUF	vs	HOU	L 10-31	41	108	1.0	11	2	9	0	1	1	0
9	Bills	67	12/11/2005	BUF	vs	NE	L 7-35	29	96	1.0	1	2	20	0	0	0	0
10	Bills	66	9/14/2009	BUF	@	NE	L 24-25	30	96	1.0	10	1	26	1	0	0	0
11	Bills	65	11/13/2005	BUF	vs	KC	W 14-3	35	100	6.0	54	3	53	0	2	1	0
12	Bills	65	12/14/2003	BUF	@	TEN	L 26-28	21	86	4.0	32	0	0	0	2	1	1
13	Bills	65	9/15/2002	BUF	@	MIN	W 45-39	15	80	5.0	45	0	0	0	2	3	1
14	Bills	65	12/2/2001	BUF	@	SF	L 0-35	11	76	2.0	10	0	0	0	1	0	0
15	Bills	64	9/8/2013	BUF	vs	NE	L 21-23	28	92	3.0	15	1	0	0	1	2	1
16	Bills	64	1/2/2011	BUF	@	NYJ	L 7-38	25	89	1.0	7	1	37	1	0	0	0
17	Bills	64	12/3/2009	BUF	vs	NYJ	L 13-19	31	95	5.0	36	0	0	0	2	0	0
18	Bills	64	10/8/2006	BUF	@	CHI	L 7-40	12	76	3.0	16	0	0	0	0	1	0
19	Bills	63	11/9/2008	BUF	@	NE	L 10-20	36	99	1.0	8	0	0	0	1	1	0
20	Bills	63	12/10/2006	BUF	@	NYJ	W 31-13	23	86	5.0	39	2	59	1	2	1	0
21	Bills	63	12/23/2001	BUF	@	ATL	L 30-33	8	71	1.0	9	2	7	1	0	0	0
22	Bills	62	11/19/2017	BUF	@	LAC	L 24-54	23	85	1.0	1	0	0	0	1	0	0
23	Bills	62	12/27/2009	BUF	@	ATL	L 3-31	5	67	3.0	16	0	0	0	2	0	0
24	Bills	62	12/23/2007	BUF	vs	NYG	L 21-38	13	75	2.0	17	2	5	0	1	2	0
25	Bills	62	11/20/2005	BUF	@	SD	L 10-48	22	84	1.0	2	0	0	0	1	0	0

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StatMuse has team, game-level data for tackles going back to the 2001 season.

More Bills Stats

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RUSH

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PASS YDS/G

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TEAM	W	L	PCT
Patriots	12	3	.800
Bills	11	4	.733
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Jets	3	12	.200

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DATE	MATCHUP			TIME (ET)
Sun 12/28	PHI	@	BUF	4:25 PM
Sun 1/4	NYJ	@	BUF	1:00 PM

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Sun 21 Dec 2025

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Pass TD Leaders

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Goff

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Rush TD Leaders

17

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Gibbs

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Rec TD Leaders

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St. Brown

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Smith-Njigba

QB Rating Leaders

112.1

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Sack Leaders

22.0

Garrett

15.0

Burns

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NFL 2025 Rankings

PPG Rankings

30.5

30.1

29.5

28.9

28.3

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Opp PPG Rankings

16.6

18.6

19.3

19.6

19.7

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Total Yards Rankings

396.7

393.1

378.7

373.1

371.5

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Rush Yards Rankings

158.9

152.1

147.9

133.9

126.3

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Pass Yards Rankings

285.7

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269.3

263.9

259.2

258.1

Sack Leaders

63.0

50.0

49.0

43.0

42.0

41.0

NFL Fantasy 2025

Fantasy RB Rankings

298

Taylor

284.8

McCaffrey

268.2

Gibbs

Fantasy WR Rankings

225.3

Smith-Njigba

219.3

Nacua

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Pickens

Fantasy TE Rankings

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Worst Record ATS

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NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - x	12	3	0	.800
Bills - x	11	4	0	.733
Dolphins - e	6	9	0	.400
Jets - e	3	12	0	.200
AFC North	W	L	T	PCT
Steelers	9	6	0	.600
Ravens	7	8	0	.467
Bengals - e	5	10	0	.333
Browns - e	3	12	0	.200
AFC South	W	L	T	PCT
Jaguars - x	11	4	0	.733
Texans	10	5	0	.667
Colts	8	7	0	.533
Titans - e	3	12	0	.200
AFC West	W	L	T	PCT
Broncos - x	12	3	0	.800
Chargers - x	11	4	0	.733
Chiefs - e	6	9	0	.400
Raiders - e	2	13	0	.133

NFC East	W	L	T	PCT
Eagles - y	10	5	0	.667
Cowboys - e	6	8	1	.433
Commanders - e	4	11	0	.267
Giants - e	2	13	0	.133
NFC North	W	L	T	PCT
Bears - x	11	4	0	.733
Packers	9	5	1	.633
Lions	8	7	0	.533
Vikings - e	7	8	0	.467
NFC South	W	L	T	PCT
Panthers	8	7	0	.533
Buccaneers	7	8	0	.467
Falcons - e	6	9	0	.400
Saints - e	5	10	0	.333
NFC West	W	L	T	PCT
Seahawks - x	12	3	0	.800
49ers - x	11	4	0	.733
Rams - x	11	4	0	.733
Cardinals - e	3	12	0	.200