Barry Sanders had the most games with 121+ rushing yards, with 48 games.

Interpreted as:

most career 121 or more rushing regular-season games by a player

	NAME	GP	RUSH YDS	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Barry Sanders B. Sanders	48	7,576	1,146	6.6	157.8	47	775	100		7.8	16.1	3
2	Walter Payton W. Payton	42	6,467	1,109	5.8	154.0	43	847	92		9.2	20.2	2
3	Eric Dickerson E. Dickerson	39	6,070	1,086	5.6	155.6	47	477	63		7.6	12.2	2
4	Emmitt Smith E. Smith	38	5,617	988	5.7	147.8	41	613	107	15	5.7	16.1	1
5	Derrick Henry D. Henry	36	5,861	889	6.6	162.8	58	407	50	62	8.1	11.3	2
6	Adrian Peterson A. Peterson	36	5,846	938	6.2	162.4	47	478	62	91	7.7	13.3	2
7	Curtis Martin C. Martin	30	4,397	839	5.2	146.6	25	639	80	64	8.0	21.3	3
8	O.J. Simpson	30	4,921	776	6.3	164.0	29	324	32		10.1	10.8	3
9	Jim Brown J. Brown	30	4,706	697	6.8	156.9	38	864	72		12.0	28.8	8
10	Chris Johnson C. Johnson	28	4,085	632	6.5	145.9	35	499	68	92	7.3	17.8	1
11	LaDainian Tomlinson L. Tomlinson	28	4,643	723	6.4	165.8	45	641	116	159	5.5	22.9	4
12	Fred Taylor F. Taylor	27	3,981	633	6.3	147.4	28	578	60	63	9.6	21.4	1
13	Jerome Bettis J. Bettis	27	3,789	741	5.1	140.3	19	254	35	12	7.3	9.4	0
14	Earl Campbell E. Campbell	27	4,306	813	5.3	159.5	37	157	25		6.3	5.8	0
15	Clinton Portis C. Portis	26	3,928	677	5.8	151.1	28	482	47	65	10.3	18.5	2
16	Shaun Alexander S. Alexander	26	4,018	691	5.8	154.5	48	303	38	56	8.0	11.7	4
17	Edgerrin James E. James	25	3,500	672	5.2	140.0	28	661	82	103	8.1	26.4	4
18	Marshall Faulk M. Faulk	24	3,773	564	6.7	157.2	32	1,082	115	113	9.4	45.1	6
19	Priest Holmes P. Holmes	23	3,472	608	5.7	151.0	41	687	69	74	10.0	29.9	5
20	LeSean McCoy L. McCoy	22	3,257	510	6.4	148.0	21	256	52	62	4.9	11.6	2
21	Frank Gore F. Gore	22	3,227	527	6.1	146.7	14	414	50	73	8.3	18.8	1
22	Corey Dillon C. Dillon	21	3,304	553	6.0	157.3	25	229	33	45	6.9	10.9	3
23	Tony Dorsett T. Dorsett	21	3,127	453	6.9	148.9	18	458	44		10.4	21.8	1
24	Saquon Barkley S. Barkley	20	3,074	468	6.6	153.7	20	486	55	74	8.8	24.3	4
25	Ahman Green A. Green	20	3,067	470	6.5	153.4	15	433	59	81	7.3	21.7	5

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StatMuse has game-level data for rushing yards going back to the 1960 season.

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