| NAME | SEASON | TM | GP | ATT | CMP | PCT | YDS | AVG | YDS/G | TD | TD% | INT | INT% | SCK | SCKY | RATE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ben Roethlisberger | 2018 |  PIT | 16 | 675 | 452 | 67.0 | 5,129 | 7.6 | 320.6 | 34 | 5.0 | 16 | 2.4 | 24 | 166 | 96.5 |
 | Philip Rivers | 2015 |  SD | 16 | 661 | 437 | 66.1 | 4,792 | 7.2 | 299.5 | 29 | 4.4 | 13 | 2.0 | 40 | 264 | 93.8 |
 | Eli Manning | 2015 |  NYG | 16 | 618 | 387 | 62.6 | 4,432 | 7.2 | 277.0 | 35 | 5.7 | 14 | 2.3 | 27 | 157 | 93.6 |
| Ben Roethlisberger | 2020 | PIT | 15 | 608 | 399 | 65.6 | 3,803 | 6.3 | 253.5 | 33 | 5.4 | 10 | 1.6 | 13 | 118 | 94.1 |
| Ben Roethlisberger | 2014 | PIT | 16 | 608 | 408 | 67.1 | 4,952 | 8.1 | 309.5 | 32 | 5.3 | 9 | 1.5 | 33 | 172 | 103.3 |
| Eli Manning | 2014 | NYG | 16 | 601 | 379 | 63.1 | 4,410 | 7.3 | 275.6 | 30 | 5.0 | 14 | 2.3 | 28 | 187 | 92.1 |
| Eli Manning | 2016 | NYG | 16 | 598 | 377 | 63.0 | 4,027 | 6.7 | 251.7 | 26 | 4.3 | 16 | 2.7 | 21 | 142 | 86.0 |
| Philip Rivers | 2019 | LAC | 16 | 591 | 390 | 66.0 | 4,615 | 7.8 | 288.4 | 23 | 3.9 | 20 | 3.4 | 34 | 222 | 88.5 |
| Eli Manning | 2011 | NYG | 16 | 589 | 359 | 61.0 | 4,933 | 8.4 | 308.3 | 29 | 4.9 | 16 | 2.7 | 28 | 199 | 92.9 |
| Ben Roethlisberger | 2013 | PIT | 16 | 584 | 375 | 64.2 | 4,261 | 7.3 | 266.3 | 28 | 4.8 | 14 | 2.4 | 42 | 282 | 92.0 |
 | Matt Schaub | 2009 |  HOU | 16 | 583 | 396 | 67.9 | 4,770 | 8.2 | 298.1 | 29 | 5.0 | 15 | 2.6 | 25 | 149 | 98.6 |
| Philip Rivers | 2011 | SD | 16 | 582 | 366 | 62.9 | 4,624 | 7.9 | 289.0 | 27 | 4.6 | 20 | 3.4 | 30 | 198 | 88.7 |
| Philip Rivers | 2016 | SD | 16 | 578 | 349 | 60.4 | 4,386 | 7.6 | 274.1 | 33 | 5.7 | 21 | 3.6 | 36 | 188 | 87.9 |
| Eli Manning | 2018 | NYG | 16 | 576 | 380 | 66.0 | 4,299 | 7.5 | 268.7 | 21 | 3.6 | 11 | 1.9 | 47 | 358 | 92.4 |
| Philip Rivers | 2017 | LAC | 16 | 575 | 360 | 62.6 | 4,515 | 7.9 | 282.2 | 28 | 4.9 | 10 | 1.7 | 18 | 120 | 96.0 |
| Matt Schaub | 2010 | HOU | 16 | 574 | 365 | 63.6 | 4,370 | 7.6 | 273.1 | 24 | 4.2 | 12 | 2.1 | 32 | 226 | 92.0 |
| Eli Manning | 2017 | NYG | 15 | 571 | 352 | 61.6 | 3,468 | 6.1 | 231.2 | 19 | 3.3 | 13 | 2.3 | 31 | 189 | 80.4 |
| Philip Rivers | 2014 | SD | 16 | 570 | 379 | 66.5 | 4,286 | 7.5 | 267.9 | 31 | 5.4 | 18 | 3.2 | 36 | 189 | 93.8 |
| Ben Roethlisberger | 2017 | PIT | 15 | 561 | 360 | 64.2 | 4,251 | 7.6 | 283.4 | 28 | 5.0 | 14 | 2.5 | 21 | 139 | 93.4 |
| Eli Manning | 2005 | NYG | 16 | 557 | 294 | 52.8 | 3,762 | 6.8 | 235.1 | 24 | 4.3 | 17 | 3.1 | 28 | 184 | 75.9 |
| Eli Manning | 2013 | NYG | 16 | 551 | 317 | 57.5 | 3,818 | 6.9 | 238.6 | 18 | 3.3 | 27 | 4.9 | 39 | 281 | 69.4 |
| Philip Rivers | 2013 | SD | 16 | 544 | 378 | 69.5 | 4,478 | 8.2 | 279.9 | 32 | 5.9 | 11 | 2.0 | 30 | 150 | 105.5 |
| Matt Schaub | 2012 | HOU | 16 | 544 | 350 | 64.3 | 4,008 | 7.4 | 250.5 | 22 | 4.0 | 12 | 2.2 | 27 | 216 | 90.7 |
 | Philip Rivers | 2020 |  IND | 16 | 543 | 369 | 68.0 | 4,169 | 7.7 | 260.6 | 24 | 4.4 | 11 | 2.0 | 19 | 118 | 97.0 |
| Philip Rivers | 2010 | SD | 16 | 541 | 357 | 66.0 | 4,710 | 8.7 | 294.4 | 30 | 5.5 | 13 | 2.4 | 38 | 227 | 101.8 |