Devin Hester has the most career touchdown returns, with 20 touchdown returns.

most career return touchdowns by 1 player in nfl history
HesterSandersWoodsonBarberReedWoodsonSharperWilliamsMitchellParrishHallMetcalfHoustonCribbsIrvinBarneyChristiansenJenkinsTalibHallMatsonTunnell20191714131313131313121212111111111010101010
NAMEGPRET TDKRKR YDSKR AVGKR YDS/GKR TDPRPR YDSPR AVGPR YDS/GPR TD
Devin HesterDevin Hester156202957,33324.947.053153,69511.723.714
Deion SandersDeion Sanders188191553,52322.718.732122,19910.411.76
Rod WoodsonRod Woodson238172204,89422.220.622602,3629.19.92
Ronde BarberRonde Barber24114000.0033010.00.11
Ed ReedEd Reed17413000.00302056.81.21
Charles WoodsonCharles Woodson254135479.40.20907368.22.90
Darren SharperDarren Sharper20513273.50.0011655.90.30
Aeneas WilliamsAeneas Williams21113000.00000.00
Brian MitchellBrian Mitchell2231360714,01423.162.844634,99910.822.49
Lemar ParrishLemar Parrish16613611,50424.79.111311,2059.27.34
Dante HallDante Hall1121242610,13623.890.562162,26110.520.26
Eric MetcalfEric Metcalf179122805,81320.832.523513,4539.819.310
Ken HoustonKen Houston1961238026.70.40513336.51.71
Josh CribbsJosh Cribbs1361142611,11326.181.782222,37510.717.53
LeRoy IrvinLeRoy Irvin1591146015.00.401471,4579.99.24
Lem BarneyLem Barney14011501,27425.59.111431,3129.29.42
Jack ChristiansenJack Christiansen8911591,32922.514.90851,08412.812.28
Janoris JenkinsJanoris Jenkins14510000.0010515.10.40
Aqib TalibAqib Talib14810000.00210.50.00
DeAngelo HallDeAngelo Hall17110413634.00.80181287.10.70
Ollie MatsonOllie Matson169101433,74626.222.26655959.23.53
Emlen TunnellEmlen Tunnell16710461,21526.47.312582,2098.613.25
Cordarrelle PattersonCordarrelle Patterson15692667,83629.550.29199.00.10
Jacoby JonesJacoby Jones12891834,94027.038.652762,6889.721.04
Darren SprolesDarren Sproles18393328,35225.245.623112,9619.516.27
StatMuse has season-level data for touchdown returns going back to the 1921 season.