most defensive touchdowns in an nfl game and lost

5 teams are tied for the most interception touchdowns in a loss, scoring 2 touchdowns. The first three are the Buffalo Bills on October 8, 2007, the Detroit Lions on October 16, 2005 and the Dallas Cowboys on November 4, 2001.

Interpreted as:
most defensive touchdowns in an NFL regular-season game and lost
TEAMINT TDLDATETMOPPRESULTTKLASTCOMBSCKSCKYINTINT YDSFFFRFR TD
1Bills
Bills
2
1
10/8/2007
vs
L
24-25
55
10
65
0.0
0
5
67
2
1
0
2Lions
Lions
2
1
10/16/2005
vs
L
20-21
49
19
68
2.0
20
3
98
3
1
0
3Cowboys
Cowboys
2
1
11/4/2001
@
L
24-27
60
14
74
4.0
15
2
100
5
3
0
4Patriots
Patriots
2
1
10/17/1999
vs
L
30-31
9.0
53
2
84
0
0
5Cardinals
Cardinals
2
1
11/26/1961
@
L
27-30
0.0
0
5
124
2
0
6Bears
Bears
1
1
12/28/2025
@
L
38-42
41
37
78
1.0
7
1
34
0
0
0
7Bengals
Bengals
1
1
11/23/2025
vs
L
20-26
33
48
81
1.0
9
1
32
0
0
0
8Saints
Saints
1
1
11/23/2025
vs
L
10-24
35
30
65
3.0
18
1
49
1
0
0
9Browns
Browns
1
1
11/16/2025
vs
L
16-23
41
23
64
5.0
26
2
32
0
1
0
10Titans
Titans
1
1
11/2/2025
vs
L
20-27
42
29
71
6.0
38
1
24
1
0
0
11Bears
Bears
1
1
9/8/2025
vs
L
24-27
38
22
60
3.0
9
1
74
0
0
0
12Bengals
Bengals
1
1
12/1/2024
vs
L
38-44
37
43
80
2.0
4
1
51
1
0
0
13Texans
Texans
1
1
11/24/2024
vs
L
27-32
49
19
68
8.0
41
1
65
0
2
0
14Raiders
Raiders
1
1
11/3/2024
@
L
24-41
42
41
83
1.0
8
1
29
0
0
0
15Rams
Rams
1
1
10/6/2024
vs
L
19-24
35
25
60
2.0
22
1
4
1
0
0
16Eagles
Eagles
1
1
12/31/2023
vs
L
31-35
49
40
89
1.0
4
1
99
1
0
0
17Jets
Jets
1
1
12/28/2023
@
L
20-37
39
20
59
1.0
8
1
37
2
2
0
18Giants
Giants
1
1
12/25/2023
@
L
25-33
55
15
70
1.0
6
1
76
2
1
0
19Titans
Titans
1
1
12/17/2023
vs
L
16-19
59
23
82
4.0
37
1
44
0
0
0
20Bears
Bears
1
1
12/17/2023
@
L
17-20
45
22
67
4.0
31
3
106
1
0
0
21Dolphins
Dolphins
1
1
12/11/2023
vs
L
27-28
42
25
67
1.0
7
1
5
1
2
0
22Colts
Colts
1
1
12/10/2023
@
L
14-34
45
23
68
0.0
0
1
36
0
0
0
23Jets
Jets
1
1
11/24/2023
vs
L
13-34
47
33
80
2.0
15
2
30
0
1
0
24Seahawks
Seahawks
1
1
11/23/2023
vs
L
13-31
43
30
73
1.0
1
1
12
1
0
0
25Ravens
Ravens
1
1
11/12/2023
vs
L
31-33
48
32
80
4.0
18
1
18
1
1
0
Results may be incomplete. StatMuse has complete team, game-level data for interception touchdowns going back to the 1940 season.

More Bills Stats

Team Leaders

PASS

556

Allen

Josh Allen

RUSH

163

Cook

James Cook III

REC

157

Shakir

Khalil Shakir
Team Rankings

PPG

28.3

4th

OPP PPG

21.5

12th

RUSH YDS/G

159.6

1st

PASS YDS/G

234.2

13th

2025 Division Standings
TEAMWLTPCT
14
3
0
.824
Bills Bills
12
5
0
.706
7
10
0
.412
3
14
0
.176
Last Game
BUF Bills

1 - 1

30

Final

33

DEN Broncos

1 - 0

Sat 17 Jan 2026

NFL 2025 Leaders

NFL 2025 Rankings

NFL Fantasy 2025

NFL 2025 Betting

NFL 2025 Standings

AFC EastWLTPCT
14
3
0
.824
Bills Bills - w
12
5
0
.706
7
10
0
.412
Jets Jets - e
3
14
0
.176
AFC NorthWLTPCT
10
7
0
.588
8
9
0
.471
6
11
0
.353
5
12
0
.294
AFC SouthWLTPCT
13
4
0
.765
12
5
0
.706
Colts Colts - e
8
9
0
.471
3
14
0
.176
AFC WestWLTPCT
14
3
0
.824
11
6
0
.647
6
11
0
.353
3
14
0
.176
NFC EastWLTPCT
11
6
0
.647
7
9
1
.441
5
12
0
.294
4
13
0
.235
NFC NorthWLTPCT
Bears Bears - y
11
6
0
.647
9
7
1
.559
9
8
0
.529
Lions Lions - e
9
8
0
.529
NFC SouthWLTPCT
8
9
0
.471
8
9
0
.471
8
9
0
.471
6
11
0
.353
NFC WestWLTPCT
14
3
0
.824
Rams Rams - w
12
5
0
.706
49ers 49ers - w
12
5
0
.706
3
14
0
.176

NFL 2025 Scores & Schedule

Scores

DATEMATCHUPSCORE
Sat
10/11
@
17-3
Sat
10/11
@
9-23
Sat
10/11
@
20-12
Sat
10/11
@
29-27
Sat
10/11
@
27-30

Schedule

DATEMATCHUPTIME (ET)
Sun
1/25
@
3:00 PM