Since 1960, Nate Clements, Tom Janik and Butch Byrd are tied for the most interception touchdowns for the Bills, scoring 5 touchdowns.
| NAME | INT TD | GP | TKL | AST | COMB | SCK | SCKY | INT | INT YDS | FF | FR | FR TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Clements | 5 | 96 | 354 | 92 | 446 | 1.5 | 1 | 23 | 341 | 13 | 6 | 0 |
| 2 | | T. Janik | 5 | 49 | 21 | 495 | 0 | 0 | ||||||
| 3 | | B. Byrd | 5 | 98 | 40 | 666 | 4 | 0 | ||||||
| 4 | | H. Jones | 4 | 144 | 5.0 | 18 | 455 | 9 | 0 | |||||
| 5 | | S. Freeman | 3 | 178 | 3.0 | 23 | 329 | 8 | 0 | |||||
| 6 | | T. Johnson | 2 | 111 | 409 | 155 | 564 | 8.0 | 45 | 6 | 80 | 8 | 3 | 1 |
| 7 | | N. Robey-Coleman | 2 | 64 | 139 | 29 | 168 | 5.0 | 25 | 3 | 63 | 2 | 4 | 1 |
| 8 | | J. Byrd | 2 | 73 | 260 | 96 | 356 | 3.0 | 21 | 22 | 409 | 11 | 5 | 0 |
| 9 | | D. Florence | 2 | 46 | 139 | 29 | 168 | 0.0 | 0 | 7 | 113 | 2 | 3 | 1 |
| 10 | | B. Scott | 2 | 87 | 263 | 87 | 350 | 7.0 | 42 | 7 | 136 | 4 | 6 | 1 |
| 11 | | J. Greer | 2 | 70 | 129 | 26 | 155 | 2.0 | 23 | 4 | 76 | 2 | 0 | 0 |
| 12 | | T. Spikes | 2 | 47 | 187 | 124 | 311 | 7.0 | 54 | 7 | 123 | 6 | 3 | 0 |
| 13 | | B. Spoon | 2 | 14 | 45 | 20 | 65 | 0.0 | 0 | 2 | 51 | 0 | 0 | 0 |
| 14 | | D. Talley | 2 | 188 | 38.5 | 11 | 179 | 12 | 0 | |||||
| 15 | | T. Greene | 2 | 128 | 37 | 628 | 13 | 0 | ||||||
| 16 | | B. Edgerson | 2 | 100 | 23 | 421 | 4 | 1 | ||||||
| 17 | | T. Sestak | 2 | 96 | 2 | 21 | 2 | 1 | ||||||
| 18 | | R. Douglas | 1 | 24 | 64 | 23 | 87 | 1.0 | 10 | 4 | 58 | 1 | 2 | 0 |
| 19 | | C. Benford | 1 | 51 | 138 | 43 | 181 | 3.0 | 22 | 7 | 136 | 4 | 4 | 1 |
| 20 | | J. Ingram | 1 | 29 | 23 | 10 | 33 | 1.0 | 8 | 2 | 56 | 0 | 0 | 0 |
| 21 |  | J. Norman | 1 | 12 | 24 | 4 | 28 | 0.0 | 0 | 1 | 16 | 1 | 2 | 0 |
| 22 | | A.J. Epenesa | 1 | 88 | 77 | 51 | 128 | 24.0 | 173.5 | 4 | 63 | 5 | 3 | 0 |
| 23 | | M. Hyde | 1 | 95 | 298 | 119 | 417 | 1.0 | 6 | 16 | 196 | 3 | 4 | 0 |
| 24 | | J. Poyer | 1 | 116 | 500 | 242 | 742 | 11.0 | 82 | 22 | 151 | 8 | 5 | 0 |
| 25 | | M. Milano | 1 | 104 | 366 | 189 | 555 | 13.5 | 99 | 10 | 156 | 4 | 11 | 1 |
StatMuse has season-level data for interception touchdowns going back to the 1921 season.
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