Since 2017, Xavien Howard has made the most interceptions, with 27 interceptions.

most interceptions since 2017
Interpreted as:
most defensive interceptions by a player since 2017
HowardJacksonByardDiggsSimmonsPoyerMathieuSlaySmithPetersWhiteWilliamsDiggsHarmonHydeJenkinsMooreFitzpatrickGilmoreFullerBradberryRamsey27252319191817171717161514141414141313131313
NAMEGPINTTKLASTCOMBSCKSCKYINT YDSINT TDFFFRFR TD
Xavien HowardXavien Howard6527158432012.0112542331
J.C. JacksonJ.C. Jackson6225129291580.002201130
Kevin ByardKevin Byard81233201404603.0292761331
Quandre DiggsQuandre Diggs7519244883321.002932210
Justin SimmonsJustin Simmons78193231124352.5192691010
Jordan PoyerJordan Poyer791836415551910.0781451650
Tyrann MathieuTyrann Mathieu7917311693807.0482182150
Darius SlayDarius Slay7617223372600.002962042
Harrison SmithHarrison Smith78173301204509.0881640540
Marcus PetersMarcus Peters6017161331941.0104714851
Tre'Davious WhiteTre'Davious White7316216632793.0202080551
Marcus WilliamsMarcus Williams7615239813201.062611310
Trevon DiggsTrevon Diggs281492181101.001852100
Duron HarmonDuron Harmon8114165582230.00610010
Micah HydeMicah Hyde7914257993561.061721340
Janoris JenkinsJanoris Jenkins6714218532710.002793300
Kenny MooreKenny Moore7514295633587.0402361410
Minkah FitzpatrickMinkah Fitzpatrick64132391133520.002893451
Stephon GilmoreStephon Gilmore6413176252011.072132320
Kyle FullerKyle Fuller8013270523220.00940100
James BradberryJames Bradberry7913256653213.019700430
Jalen RamseyJalen Ramsey7513256432990.00900310
Marshon LattimoreMarshon Lattimore7313245532980.001331550
Donte JacksonDonte Jackson5512167422091.081560220
Tashaun GipsonTashaun Gipson7412215672821.022371030
StatMuse has season-level data for interceptions going back to the 1940 season.