Frank Gore has lost the most career games by a running back when rushing for >0 yards, with 123 losses.
Interpreted as:
most lost in the regular season rushing yards by running back| NAME | L | RUSH YDS | GP | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | F. Gore | 123 | 16,000 | 239 | 3,729 | 4.3 | 66.9 | 81 | 3,977 | 483 | 695 | 8.2 | 16.6 | 18 |
| 2 |  | S. Jackson | 107 | 11,438 | 159 | 2,761 | 4.1 | 71.9 | 69 | 3,675 | 460 | 625 | 8.0 | 23.1 | 8 |
| 3 |  | E. Smith | 101 | 18,359 | 224 | 4,402 | 4.2 | 82.0 | 164 | 3,217 | 512 | 127 | 6.3 | 14.4 | 11 |
| 4 |  | A. Peterson | 95 | 14,918 | 183 | 3,226 | 4.6 | 81.5 | 120 | 2,474 | 305 | 423 | 8.1 | 13.5 | 6 |
| 5 | | T. Jones | 92 | 10,595 | 175 | 2,675 | 4.0 | 60.5 | 68 | 1,935 | 300 | 399 | 6.5 | 11.1 | 3 |
| 6 |  | O.J. Simpson | 90 | 11,246 | 134 | 2,397 | 4.7 | 83.9 | 61 | 2,128 | 201 | 10.6 | 15.9 | 14 | |
| 7 | | H. Walker | 89 | 8,227 | 155 | 1,952 | 4.2 | 53.1 | 61 | 4,707 | 494 | 9.5 | 30.4 | 19 | |
| 8 |  | J. Bettis | 87 | 13,662 | 189 | 3,477 | 3.9 | 72.3 | 91 | 1,449 | 200 | 100 | 7.2 | 7.7 | 3 |
| 9 | | W. Dunn | 85 | 10,967 | 180 | 2,668 | 4.1 | 60.9 | 49 | 4,331 | 508 | 591 | 8.5 | 24.1 | 15 |
| 10 | | C. Dillon | 83 | 11,241 | 147 | 2,618 | 4.3 | 76.5 | 82 | 1,913 | 244 | 278 | 7.8 | 13.0 | 7 |
| 11 |  | M. Faulk | 81 | 12,279 | 173 | 2,835 | 4.3 | 71.0 | 100 | 6,818 | 761 | 598 | 9.0 | 39.4 | 36 |
| 12 | | J. Wilder | 80 | 6,017 | 112 | 1,578 | 3.8 | 53.7 | 37 | 3,437 | 424 | 8.1 | 30.7 | 10 | |
| 13 |  | M. Forte | 79 | 9,796 | 146 | 2,356 | 4.2 | 67.1 | 54 | 4,672 | 554 | 724 | 8.4 | 32.0 | 21 |
| 14 |  | B. Sanders | 79 | 15,269 | 153 | 3,062 | 5.0 | 99.8 | 99 | 2,921 | 352 | 8.3 | 19.1 | 10 | |
| 15 | | M. Allen | 79 | 12,248 | 217 | 3,005 | 4.1 | 56.4 | 123 | 5,347 | 580 | 9.2 | 24.6 | 21 | |
| 16 |  | W. Payton | 79 | 16,726 | 188 | 3,820 | 4.4 | 89.0 | 110 | 4,539 | 487 | 9.3 | 24.1 | 15 | |
| 17 | | L. Centers | 78 | 2,053 | 130 | 571 | 3.6 | 15.8 | 14 | 4,815 | 590 | 254 | 8.2 | 37.0 | 21 |
| 18 | | J. Brooks | 78 | 7,969 | 154 | 1,675 | 4.8 | 51.7 | 49 | 3,587 | 377 | 9.5 | 23.3 | 29 | |
| 19 |  | C. Martin | 77 | 14,101 | 168 | 3,518 | 4.0 | 83.9 | 90 | 3,329 | 484 | 409 | 6.9 | 19.8 | 10 |
| 20 | | C. Garner | 77 | 7,105 | 142 | 1,531 | 4.6 | 50.0 | 39 | 3,696 | 416 | 456 | 8.9 | 26.0 | 12 |
| 21 | | E. Byner | 76 | 8,266 | 179 | 2,086 | 4.0 | 46.2 | 56 | 4,385 | 486 | 9.0 | 24.5 | 14 | |
| 22 | | J. Riggins | 76 | 11,352 | 173 | 2,916 | 3.9 | 65.6 | 104 | 2,090 | 250 | 8.4 | 12.1 | 12 | |
| 23 | | J. Charles | 74 | 7,563 | 116 | 1,406 | 5.4 | 65.2 | 44 | 2,581 | 307 | 438 | 8.4 | 22.3 | 20 |
| 24 | | M. Jones-Drew | 74 | 8,170 | 123 | 1,842 | 4.4 | 66.4 | 68 | 2,933 | 345 | 462 | 8.5 | 23.8 | 11 |
| 25 | | O. Anderson | 74 | 10,283 | 158 | 2,545 | 4.0 | 65.1 | 80 | 3,000 | 366 | 8.2 | 19.0 | 5 | |
StatMuse has game-level data for rushing yards going back to the 1960 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |