Between the 2010 and 2019 seasons, the San Francisco 49ers had their most passing yards in a game against the Cardinals on November 17, 2019, with 424 yards.
Interpreted as:
most passing yards in a regular-season game 2010s 49ers| TEAM | YDS | DATE | TM | OPP | RESULT | CMP | ATT | PCT | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 424 | 11/17/2019 | vs | W 36-26 | 34 | 45 | 75.6 | 9.4 | 4 | 2 | 115.4 | 8.9 | 4.4 | 2 | 16 | ||
| 2 | | 49ers | 414 | 12/2/2018 | @ | L 16-43 | 30 | 48 | 62.5 | 8.6 | 2 | 1 | 95.3 | 4.2 | 2.1 | 3 | 28 | ||
| 3 | | 49ers | 412 | 9/8/2013 | vs | W 34-28 | 27 | 39 | 69.2 | 10.6 | 3 | 0 | 129.4 | 7.7 | 0.0 | 2 | 8 | ||
| 4 | | 49ers | 398 | 11/6/2016 | vs | L 23-41 | 24 | 39 | 61.5 | 10.2 | 2 | 1 | 102.3 | 5.1 | 2.6 | 1 | 5 | ||
| 5 | | 49ers | 384 | 12/8/2019 | @ | W 48-46 | 27 | 36 | 75.0 | 10.7 | 5 | 1 | 137.0 | 13.9 | 2.8 | 3 | 30 | ||
| 6 | | 49ers | 381 | 12/17/2017 | vs | W 25-23 | 31 | 43 | 72.1 | 8.9 | 1 | 0 | 106.8 | 2.3 | 0.0 | 3 | 18 | ||
| 7 | | 49ers | 356 | 11/14/2010 | vs | W 23-20 | 17 | 28 | 60.7 | 12.7 | 1 | 0 | 116.7 | 3.6 | 0.0 | 5 | 33 | ||
| 8 | | 49ers | 354 | 1/3/2016 | vs | W 19-16 | 28 | 44 | 63.6 | 8.0 | 1 | 1 | 86.7 | 2.3 | 2.3 | 1 | 4 | ||
| 9 | | 49ers | 353 | 10/8/2017 | @ | L 23-26 | 29 | 46 | 63.0 | 7.7 | 2 | 0 | 101.1 | 4.3 | 0.0 | 2 | 17 | ||
| 10 | | 49ers | 349 | 10/7/2018 | vs | L 18-28 | 34 | 54 | 63.0 | 6.5 | 2 | 2 | 78.4 | 3.7 | 3.7 | 4 | 49 | ||
| 11 | | 49ers | 343 | 10/13/2014 | @ | W 31-17 | 22 | 35 | 62.9 | 9.8 | 3 | 0 | 123.9 | 8.6 | 0.0 | 0 | 0 | ||
| 12 | | 49ers | 340 | 10/18/2015 | vs | W 25-20 | 16 | 27 | 59.3 | 12.6 | 2 | 0 | 128.2 | 7.4 | 0.0 | 3 | 14 | ||
| 13 | | 49ers | 335 | 9/20/2015 | @ | L 18-43 | 33 | 46 | 71.7 | 7.3 | 2 | 0 | 106.7 | 4.3 | 0.0 | 5 | 37 | ||
| 14 | | 49ers | 334 | 12/10/2017 | @ | W 26-16 | 20 | 33 | 60.6 | 10.1 | 1 | 1 | 92.2 | 3.0 | 3.0 | 2 | 20 | ||
| 15 | | 49ers | 332 | 12/9/2018 | vs | W 20-14 | 20 | 33 | 60.6 | 10.1 | 2 | 1 | 102.1 | 6.1 | 3.0 | 3 | 27 | ||
| 16 | | 49ers | 332 | 9/21/2017 | vs | L 39-41 | 23 | 37 | 62.2 | 9.0 | 2 | 1 | 98.0 | 5.4 | 2.7 | 4 | 24 | ||
| 17 | | 49ers | 318 | 11/29/2015 | vs | L 13-19 | 25 | 36 | 69.4 | 8.8 | 1 | 1 | 94.4 | 2.8 | 2.8 | 2 | 17 | ||
| 18 | | 49ers | 317 | 10/31/2019 | @ | W 28-25 | 28 | 37 | 75.7 | 8.6 | 4 | 0 | 136.9 | 10.8 | 0.0 | 1 | 7 | ||
| 19 | | 49ers | 312 | 9/15/2019 | @ | W 41-17 | 18 | 26 | 69.2 | 12.0 | 3 | 1 | 132.2 | 11.5 | 3.8 | 0 | 0 | ||
| 20 | | 49ers | 310 | 12/29/2013 | @ | W 23-20 | 21 | 34 | 61.8 | 9.1 | 2 | 0 | 111.2 | 5.9 | 0.0 | 2 | 18 | ||
| 21 | | 49ers | 310 | 10/7/2012 | vs | W 45-3 | 19 | 25 | 76.0 | 12.4 | 3 | 0 | 156.7 | 12.0 | 0.0 | 0 | 0 | ||
| 22 | | 49ers | 309 | 10/10/2010 | vs | L 24-27 | 25 | 39 | 64.1 | 7.9 | 3 | 2 | 92.8 | 7.7 | 5.1 | 2 | 19 | ||
| 23 | | 49ers | 301 | 10/19/2014 | @ | L 17-42 | 27 | 46 | 58.7 | 6.5 | 2 | 1 | 83.7 | 4.3 | 2.2 | 6 | 53 | ||
| 24 | | 49ers | 298 | 9/30/2018 | @ | L 27-29 | 23 | 37 | 62.2 | 8.1 | 2 | 2 | 82.9 | 5.4 | 5.4 | 1 | 10 | ||
| 25 | | 49ers | 296 | 11/27/2016 | @ | L 24-31 | 29 | 46 | 63.0 | 6.4 | 3 | 1 | 94.1 | 6.5 | 2.2 | 2 | 14 | ||
STL
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |