Since 2000, the San Francisco 49ers have their most passing yards in a game against the Cardinals on November 17, 2019, with 424 yards.
Interpreted as:
most passing yards in a regular-season game since 2000 49ers| TEAM | YDS | DATE | TM | OPP | RESULT | CMP | ATT | PCT | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 424 | 11/17/2019 | vs | W 36-26 | 34 | 45 | 75.6 | 9.4 | 4 | 2 | 115.4 | 8.9 | 4.4 | 2 | 16 | ||
| 2 | | 49ers | 417 | 10/10/2004 | vs | W 31-28 | 38 | 57 | 66.7 | 7.3 | 2 | 0 | 99.8 | 3.5 | 0.0 | 5 | 26 | ||
| 3 | | 49ers | 414 | 12/2/2018 | @ | L 16-43 | 30 | 48 | 62.5 | 8.6 | 2 | 1 | 95.3 | 4.2 | 2.1 | 3 | 28 | ||
| 4 | | 49ers | 412 | 12/30/2024 | vs | L 34-40 | 30 | 40 | 75.0 | 10.3 | 3 | 2 | 111.7 | 7.5 | 5.0 | 2 | 12 | ||
| 5 | | 49ers | 412 | 9/8/2013 | vs | W 34-28 | 27 | 39 | 69.2 | 10.6 | 3 | 0 | 129.4 | 7.7 | 0.0 | 2 | 8 | ||
| 6 | | 49ers | 402 | 12/17/2000 | vs | W 17-0 | 36 | 44 | 81.8 | 9.1 | 2 | 0 | 119.9 | 4.5 | 0.0 | 4 | 23 | ||
| 7 | | 49ers | 398 | 11/6/2016 | vs | L 23-41 | 24 | 39 | 61.5 | 10.2 | 2 | 1 | 102.3 | 5.1 | 2.6 | 1 | 5 | ||
| 8 | | 49ers | 384 | 12/8/2019 | @ | W 48-46 | 27 | 36 | 75.0 | 10.7 | 5 | 1 | 137.0 | 13.9 | 2.8 | 3 | 30 | ||
| 9 | | 49ers | 381 | 12/17/2017 | vs | W 25-23 | 31 | 43 | 72.1 | 8.9 | 1 | 0 | 106.8 | 2.3 | 0.0 | 3 | 18 | ||
| 10 | | 49ers | 369 | 10/23/2022 | vs | L 23-44 | 29 | 46 | 63.0 | 8.0 | 2 | 2 | 84.4 | 4.3 | 4.3 | 5 | 26 | ||
| 11 | | 49ers | 368 | 12/10/2023 | vs | W 28-16 | 19 | 27 | 70.4 | 13.6 | 2 | 1 | 122.1 | 7.4 | 3.7 | 3 | 14 | ||
| 12 | | 49ers | 365 | 10/29/2023 | vs | L 17-31 | 22 | 31 | 71.0 | 11.8 | 1 | 2 | 94.2 | 3.2 | 6.5 | 2 | 18 | ||
| 13 | | 49ers | 356 | 11/14/2010 | vs | W 23-20 | 17 | 28 | 60.7 | 12.7 | 1 | 0 | 116.7 | 3.6 | 0.0 | 5 | 33 | ||
| 14 | | 49ers | 354 | 1/3/2016 | vs | W 19-16 | 28 | 44 | 63.6 | 8.0 | 1 | 1 | 86.7 | 2.3 | 2.3 | 1 | 4 | ||
| 15 | | 49ers | 353 | 11/10/2024 | @ | W 23-20 | 25 | 36 | 69.4 | 9.8 | 2 | 0 | 119.3 | 5.6 | 0.0 | 3 | 15 | ||
| 16 | | 49ers | 353 | 10/8/2017 | @ | L 23-26 | 29 | 46 | 63.0 | 7.7 | 2 | 0 | 101.1 | 4.3 | 0.0 | 2 | 17 | ||
| 17 | | 49ers | 349 | 10/7/2018 | vs | L 18-28 | 34 | 54 | 63.0 | 6.5 | 2 | 2 | 78.4 | 3.7 | 3.7 | 4 | 49 | ||
| 18 | | 49ers | 347 | 10/12/2025 | @ | L 19-30 | 27 | 39 | 69.2 | 8.9 | 0 | 2 | 75.5 | 0.0 | 5.1 | 6 | 51 | ||
| 19 | | 49ers | 344 | 12/14/2003 | @ | L 38-41 | 26 | 33 | 78.8 | 10.4 | 2 | 0 | 130.3 | 6.1 | 0.0 | 1 | 13 | ||
| 20 | | 49ers | 343 | 9/27/2020 | @ | W 36-9 | 25 | 36 | 69.4 | 9.5 | 1 | 0 | 108.9 | 2.8 | 0.0 | 2 | 16 | ||
| 21 | | 49ers | 343 | 10/13/2014 | @ | W 31-17 | 22 | 35 | 62.9 | 9.8 | 3 | 0 | 123.9 | 8.6 | 0.0 | 0 | 0 | ||
| 22 | | 49ers | 342 | 10/2/2025 | @ | W 26-23 | 33 | 49 | 67.3 | 7.0 | 2 | 0 | 100.9 | 4.1 | 0.0 | 1 | 9 | ||
| 23 | | 49ers | 340 | 1/9/2022 | @ | W 27-24 | 24 | 33 | 72.7 | 10.3 | 2 | 2 | 100.6 | 6.1 | 6.1 | 3 | 26 | ||
| 24 | | 49ers | 340 | 10/18/2015 | vs | W 25-20 | 16 | 27 | 59.3 | 12.6 | 2 | 0 | 128.2 | 7.4 | 0.0 | 3 | 14 | ||
| 25 | | 49ers | 338 | 10/4/2020 | vs | L 20-25 | 32 | 45 | 71.1 | 7.5 | 1 | 2 | 81.5 | 2.2 | 4.4 | 5 | 37 | ||
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |