Dan Marino has the most passing yards in a game against the Patriots, with 473 yards on September 4, 1994.

most passing yards in a single game against patriots
Interpreted as:
most passing yards by a player in a single regular-season game against patriots
9/4/1994Marino10/13/1961Lee10/17/2021Prescott11/2/2014Manning9/22/1996Brunell9/29/2013Ryan9/12/2011Henne11/18/2001Warner11/3/2013Roethlisberger11/27/2011Young11/21/2010Manning12/8/2013Campbell11/23/1997Marino9/18/2016Tannehill11/14/2010Roethlisberger11/5/1989O'Brien9/16/1962Blanda9/23/2012Flacco11/22/2004Green9/18/2011Rivers9/16/2018Bortles11/30/2009Brees9/25/2011Fitzpatrick473457445438432421416401400400396391389387387386386382381378376371369
NAMEDATETMOPPYDSCMPATTPCTAVGTDTD%INTINT%SCKSCKYRATE
Dan MarinoDan Marino9/4/1994MIAMIAvsNENE473234254.811.3511.912.4217124.3
Jacky LeeJacky Lee10/13/1961HOUHOU@BOSBOS457274165.911.124.924.999.3
Dak PrescottDak Prescott10/17/2021DALDAL@NENE445365170.68.735.912.000108.7
Peyton ManningPeyton Manning11/2/2014DENDEN@NENE438345759.67.723.523.51980.9
Mark BrunellMark Brunell9/22/1996JAXJAX@NENE432233959.011.137.712.6219112.3
Matt RyanMatt Ryan9/29/2013ATLATLvsNENE421345463.07.823.711.922291.7
Chad HenneChad Henne9/12/2011MIAMIAvsNENE416304961.28.524.112.042693.6
Kurt WarnerKurt Warner11/18/2001STLSTL@NENE401304271.49.537.124.815105.4
Ben RoethlisbergerBen Roethlisberger11/3/2013PITPIT@NENE400284858.38.348.324.252995.8
Vince YoungVince Young11/27/2011PHIPHIvsNENE400264854.28.312.112.12780.2
Peyton ManningPeyton Manning11/21/2010INDIND@NENE396385273.17.647.735.80096.3
Jason CampbellJason Campbell12/8/2013CLECLE@NENE391294465.98.936.800.015116.8
Dan MarinoDan Marino11/23/1997MIAMIA@NENE389386063.36.500.035.031961.0
Ryan TannehillRyan Tannehill9/18/2016MIAMIA@NENE387324571.18.624.424.40093.5
Ben RoethlisbergerBen Roethlisberger11/14/2010PITPITvsNENE387304961.27.936.112.053897.9
Ken O'BrienKen O'Brien11/5/1989NYJNYJ@NENE386222975.913.326.900.0212140.4
George BlandaGeorge Blanda9/16/1962HOUHOU@BOSBOS386203655.610.738.3411.181.3
Joe FlaccoJoe Flacco9/23/2012BALBALvsNENE382283971.89.837.712.600117.7
Trent GreenTrent Green11/22/2004KCKCvsNENE381274264.39.124.812.442899.4
Philip RiversPhilip Rivers9/18/2011SDSD@NENE378294072.59.525.025.02697.7
Blake BortlesBlake Bortles9/16/2018JAXJAXvsNENE376294564.48.448.912.200111.0
Drew BreesDrew Brees11/30/2009NONOvsNENE371182378.316.1521.700.014158.3
Ryan FitzpatrickRyan Fitzpatrick9/25/2011BUFBUFvsNENE369274067.59.225.025.00092.6
Alex SmithAlex Smith9/7/2017KCKC@NENE368283580.010.5411.400.0316148.6
Aaron RodgersAaron Rodgers11/30/2014GBGBvsNENE368243863.29.725.300.0320112.6
Results may be incomplete. StatMuse has complete game-level data for passing yards going back to the 1950 season.