O.J. Simpson has the most rushing yards in a loss, with 273 yards against the Lions on November 25, 1976.
Interpreted as:
most rushing yards by a player in a regular-season loss all-time| NAME | RUSH YDS | L | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 1 | 11/25/1976 |  BUF | @ |  DET | 29 | 9.4 | 2 | 0 | 0 | 0 | ||
| 2 |  | R. Williams | 228 | 1 | 12/1/2002 |  MIA | @ | BUF | 27 | 8.4 | 2 | 7 | 4 | 6 | 1.8 | 0 |
| 3 | | J. Charles | 226 | 1 | 12/23/2012 |  KC | vs |  IND | 22 | 10.3 | 1 | 4 | 1 | 3 | 4.0 | 0 |
| 4 | | K. Moreno | 224 | 1 | 11/24/2013 |  DEN | @ |  NE | 37 | 6.1 | 1 | 6 | 1 | 1 | 6.0 | 0 |
| 5 | | G. Riggs | 221 | 1 | 9/17/1989 |  WAS | vs |  PHI | 29 | 7.6 | 1 | 0 | 0 | 0 | ||
| 6 | | J. Fuqua | 218 | 1 | 12/20/1970 |  PIT | @ | PHI | 20 | 10.9 | 2 | 38 | 3 | 12.7 | 0 | |
| 7 |  | A. Peterson | 210 | 1 | 12/2/2012 |  MIN | @ |  GB | 21 | 10.0 | 1 | 10 | 1 | 2 | 10.0 | 0 |
| 8 | | T. Jones | 210 | 1 | 10/18/2009 |  NYJ | vs | BUF | 22 | 9.5 | 1 | 17 | 2 | 2 | 8.5 | 0 |
| 9 | | R. Mayes | 203 | 1 | 12/7/1986 |  NO | vs | MIA | 28 | 7.3 | 2 | 22 | 2 | 11.0 | 0 | |
| 10 | | O.J. Simpson | 203 | 1 | 12/5/1976 | BUF | @ | MIA | 24 | 8.5 | 1 | 12 | 2 | 6.0 | 0 | |
| 11 |  | C. Johnson | 197 | 1 | 9/20/2009 |  TEN | vs |  HOU | 16 | 12.3 | 2 | 87 | 9 | 11 | 9.7 | 1 |
| 12 | | P. Holmes | 197 | 1 | 11/24/2002 | KC | @ |  SEA | 23 | 8.6 | 2 | 110 | 7 | 7 | 15.7 | 1 |
| 13 | | G. Riggs | 197 | 1 | 12/8/1985 |  ATL | @ | KC | 26 | 7.6 | 1 | 22 | 3 | 7.3 | 0 | |
| 14 | | W. Montgomery | 197 | 1 | 11/4/1979 | PHI | vs |  CLE | 30 | 6.6 | 1 | 40 | 3 | 13.3 | 0 | |
| 15 | | O.J. Simpson | 197 | 1 | 11/17/1975 | BUF | @ |  CIN | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |
| 16 | | R. Edwards | 196 | 1 | 12/13/1998 | NE | @ |  STL | 24 | 8.2 | 0 | 0 | 0 | 0 | ||
| 17 | | D. Williams | 194 | 1 | 10/31/1976 |  SF | @ |  STL | 34 | 5.7 | 3 | 8 | 1 | 8.0 | 0 | |
| 18 |  | C. Hyde | 193 | 1 | 12/11/2016 | SF | vs | NYJ | 17 | 11.4 | 0 | 7 | 1 | 1 | 7.0 | 1 |
| 19 | | O. Anderson | 193 | 1 | 9/2/1979 | STL | vs |  DAL | 21 | 9.2 | 1 | 0 | 0 | 0 | ||
| 20 | | A. Green | 192 | 1 | 11/10/2003 | GB | vs | PHI | 29 | 6.6 | 1 | 32 | 3 | 4 | 10.7 | 1 |
| 21 |  | M. Faulk | 192 | 1 | 11/29/1998 | IND | @ |  BAL | 17 | 11.3 | 1 | 75 | 7 | 10.7 | 1 | |
| 22 | | E. Pegram | 192 | 1 | 9/19/1993 | ATL | @ | SF | 27 | 7.1 | 0 | 5 | 1 | 5.0 | 0 | |
| 23 |  | E. Dickerson | 192 | 1 | 9/25/1983 |  RAM | @ |  NYJ | 28 | 6.9 | 2 | 45 | 5 | 9.0 | 0 | |
| 24 | | J. Olszewski | 190 | 1 | 11/15/1959 | WAS | vs | CLE | 18 | 10.6 | 1 | 0 | 1 | 0.0 | 0 | |
| 25 | | O.J. Simpson | 189 | 1 | 10/29/1972 | BUF | vs | PIT | 22 | 8.6 | 1 | 7 | 3 | 2.3 | 0 | |
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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