Adrian Peterson has rushed for the most yards against a team in the regular season and playoffs, with 508 yards against the Packers in 2012.
| NAME | RUSH YDS | OPP | SEASON | TM | GP | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | A. Peterson | 508 | 2012 | 3 | 77 | 6.6 | 169.3 | 2 | 20 | 3 | 7 | 6.7 | 6.7 | 1 | ||
| 2 |  | J. Lewis | 500 | 2003 | 2 | 52 | 9.6 | 250.0 | 4 | 21 | 3 | 5 | 7.0 | 10.5 | 0 | ||
| 3 |  | O.J. Simpson | 469 | 1973 | 2 | 51 | 9.2 | 234.5 | 3 | 0 | 0 | 0.0 | 0 | ||||
| 4 |  | D. Henry | 462 | 2020 | 2 | 56 | 8.3 | 231.0 | 4 | 52 | 2 | 5 | 26.0 | 26.0 | 0 | ||
| 5 |  | S. Barkley | 460 | 2024 | 2 | 52 | 8.8 | 230.0 | 4 | 74 | 8 | 8 | 9.3 | 37.0 | 0 | ||
| 6 |  | L. Tomlinson | 430 | 2003 | 2 | 59 | 7.3 | 215.0 | 3 | 41 | 15 | 23 | 2.7 | 20.5 | 0 | ||
| 7 |  | J. Ajayi | 420 | 2016 | 2 | 60 | 7.0 | 210.0 | 2 | 5 | 2 | 2 | 2.5 | 2.5 | 0 | ||
| 8 | | S. Barkley | 414 | 2024 | 3 | 70 | 5.9 | 138.0 | 7 | 56 | 3 | 6 | 18.7 | 18.7 | 0 | ||
| 9 |  | D. Henry | 413 | 2024 | 3 | 63 | 6.6 | 137.7 | 3 | 27 | 2 | 2 | 13.5 | 9.0 | 0 | ||
| 10 |  | E. Smith | 409 | 1993 | 2 | 53 | 7.7 | 204.5 | 1 | 26 | 4 | 6.5 | 13.0 | 0 | |||
| 11 |  | B. Sanders | 403 | 1994 | 2 | 46 | 8.8 | 201.5 | 0 | 26 | 3 | 8.7 | 13.0 | 0 | |||
| 12 | | P. Holmes | 400 | 1998 | 2 | 63 | 6.3 | 200.0 | 3 | 5 | 2 | 2.5 | 2.5 | 0 | |||
| 13 |  | W. Payton | 397 | 1977 | 2 | 64 | 6.2 | 198.5 | 1 | 11 | 2 | 5.5 | 5.5 | 0 | |||
| 14 | | T. Davis | 386 | 1998 | 2 | 59 | 6.5 | 193.0 | 1 | 17 | 2 | 8.5 | 8.5 | 1 | |||
| 15 |  | M. Faulk | 385 | 2001 | 2 | 45 | 8.6 | 192.5 | 4 | 64 | 7 | 8 | 9.1 | 32.0 | 0 | ||
| 16 | | W. Payton | 368 | 1977 | 2 | 55 | 6.7 | 184.0 | 4 | 5 | 1 | 5.0 | 2.5 | 0 | |||
| 17 |  | J. Brown | 367 | 1963 | 2 | 53 | 6.9 | 183.5 | 1 | 21 | 3 | 7.0 | 10.5 | 1 | |||
| 18 | | S. Alexander | 366 | 2004 | 3 | 60 | 6.1 | 122.0 | 1 | 32 | 3 | 4 | 10.7 | 10.7 | 0 | ||
| 19 | | E. Smith | 365 | 1995 | 3 | 75 | 4.9 | 121.7 | 4 | 70 | 9 | 7.8 | 23.3 | 0 | |||
| 20 | | C. Dillon | 360 | 1999 | 2 | 56 | 6.4 | 180.0 | 3 | 21 | 3 | 7 | 7.0 | 10.5 | 0 | ||
| 21 | | J. Anderson | 360 | 1998 | 2 | 53 | 6.8 | 180.0 | 3 | 40 | 4 | 10.0 | 20.0 | 1 | |||
| 22 | | C. Portis | 359 | 2003 | 2 | 45 | 8.0 | 179.5 | 6 | 115 | 7 | 10 | 16.4 | 57.5 | 0 | ||
| 23 | | T. Barber | 357 | 2006 | 2 | 46 | 7.8 | 178.5 | 3 | 40 | 6 | 9 | 6.7 | 20.0 | 0 | ||
| 24 | | C. Gilchrist | 357 | 1963 | 2 | 67 | 5.3 | 178.5 | 6 | 1 | 1 | 1.0 | 0.5 | 0 | |||
| 25 |  | F. Gore | 356 | 2006 | 2 | 53 | 6.7 | 178.0 | 0 | 60 | 8 | 11 | 7.5 | 30.0 | 1 | ||
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