Colin Kaepernick has the most rushing yards by a quarterback in a regular-season or postseason game, with 181 yards in the 2012 NFC divisional game against the Packers on January 12, 2013.

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	REC TD
1	Colin Kaepernick C. Kaepernick	181	1/12/2013	SF	vs	GB	16	11.3	2	0	0	0	0
2	Justin Fields J. Fields	178	11/6/2022	CHI	vs	MIA	15	11.9	1	0	0	0	0
3	Michael Vick M. Vick	173	12/1/2002	ATL	@	MIN	10	17.3	2	0	0	0	0
4	Michael Vick M. Vick	166	11/26/2006	ATL	vs	NO	12	13.8	0	0	0	0	0
5	Jalen Hurts J. Hurts	157	11/27/2022	PHI	vs	GB	17	9.2	0	0	0	0	0
6	Lamar Jackson L. Jackson	152	10/13/2019	BAL	vs	CIN	19	8.0	1	0	0	0	0
7	Colin Kaepernick C. Kaepernick	151	12/20/2014	SF	vs	SD	7	21.6	1	0	0	0	0
8	Tobin Rote T. Rote	150	11/18/1951	GB	@	CHB	14	10.7	0
9	Justin Fields J. Fields	147	11/13/2022	CHI	vs	DET	13	11.3	2	0	0	0	0
10	Charley Trippi C. Trippi	145	12/16/1951	CHC	@	CHB	13	11.2	2
11	Lamar Jackson L. Jackson	143	1/11/2020	BAL	vs	TEN	20	7.2	0	0	0	0	0
12	Michael Vick M. Vick	141	12/7/2003	ATL	vs	CAR	14	10.1	1	0	0	0	0
13	Robert Griffin III R. Griffin III	138	10/14/2012	WAS	vs	MIN	13	10.6	2	0	0	0	0
14	Lamar Jackson L. Jackson	136	1/10/2021	BAL	@	TEN	16	8.5	1	0	0	0	0
15	Josh Allen J. Allen	135	12/2/2018	BUF	@	MIA	9	15.0	0	0	0	0	0
16	Justin Fields J. Fields	132	1/1/2023	CHI	@	DET	10	13.2	0	0	0	0	0
17	Billy Kilmer B. Kilmer	131	10/8/1961	SF	vs	LA	19	6.9	2	0	0		0
18	Tobin Rote T. Rote	131	11/22/1951	GB	@	DET	15	8.7	1
19	Bob Davis B. Davis	131	11/19/1944	BOS	vs	BKN	17	7.7	1
20	Colin Kaepernick C. Kaepernick	130	1/19/2014	SF	@	SEA	11	11.8	0	0	0	0	0
21	Michael Vick M. Vick	130	12/19/2010	PHI	@	NYG	10	13.0	1	0	0	0	0
22	Jack Concannon J. Concannon	129	12/4/1966	PHI	vs	PIT	15	8.6	1	0	0		0
23	Bill Shepherd B. Shepherd	129	11/3/1935	BOS	vs	PHI	19	6.8	1
24	Jayden Daniels J. Daniels	127	12/29/2024	WAS	vs	ATL	16	7.9	0	0	0	0	0
25	Michael Vick M. Vick	127	9/17/2006	ATL	vs	TB	14	9.1	1	0	0	0	0