O.J. Simpson has rushed for the most yards by a running back in a Week-1 game, with 250 yards against the Patriots on September 16, 1973.
| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 250 | 9/16/1973 |  BUF | @ |  NE | 29 | 8.6 | 2 | 0 | 0 | 0 | ||
| 2 |  | A. Foster | 231 | 9/12/2010 |  HOU | vs |  IND | 33 | 7.0 | 3 | 7 | 1 | 1 | 7.0 | 0 |
| 3 | | M. Turner | 220 | 9/7/2008 |  ATL | vs |  DET | 22 | 10.0 | 2 | 6 | 1 | 1 | 6.0 | 0 |
| 4 | | E. George | 216 | 8/31/1997 |  TEN | vs |  OAK | 35 | 6.2 | 1 | 0 | 0 | 0 | ||
| 5 | | G. Rogers | 206 | 9/4/1983 |  NO | vs |  STL | 24 | 8.6 | 2 | 0 | 0 | 0 | ||
| 6 | | G. Riggs | 202 | 9/2/1984 | ATL | @ | NO | 35 | 5.8 | 2 | 0 | 0 | 0 | ||
| 7 | | D. Staley | 201 | 9/3/2000 |  PHI | @ |  DAL | 26 | 7.7 | 1 | 61 | 4 | 7 | 15.3 | 0 |
| 8 | | N. Bulaich | 198 | 9/19/1971 |  BAL | vs |  NYJ | 22 | 9.0 | 1 | 0 | 0 | 0 | ||
| 9 |  | C. Martin | 196 | 9/12/2004 |  NYJ | vs |  CIN | 29 | 6.8 | 1 | 7 | 3 | 3 | 2.3 | 1 |
| 10 | | A. Ameche | 194 | 9/25/1955 | BAL | vs |  CHB | 21 | 9.2 | 1 | |||||
| 11 |  | E. Dickerson | 193 | 9/7/1986 |  RAM | @ | STL | 38 | 5.1 | 2 | 0 | 0 | 0 | ||
| 12 | | O. Anderson | 193 | 9/2/1979 | STL | vs | DAL | 21 | 9.2 | 1 | 0 | 0 | 0 | ||
| 13 | | G. Hearst | 187 | 9/6/1998 |  SF | vs | NYJ | 20 | 9.4 | 2 | 38 | 2 | 19.0 | 0 | |
| 14 |  | L. McCoy | 184 | 9/9/2013 | PHI | @ |  WAS | 31 | 5.9 | 1 | 5 | 1 | 1 | 5.0 | 0 |
| 15 | | W. Galimore | 181 | 9/16/1962 | CHI | @ | SF | 22 | 8.2 | 2 | 7 | 1 | 7.0 | 0 | |
| 16 |  | A. Peterson | 180 | 9/13/2009 |  MIN | @ |  CLE | 25 | 7.2 | 3 | 18 | 1 | 1 | 18.0 | 0 |
| 17 | | C. Brown | 175 | 9/9/2007 |  TEN | @ |  JAX | 19 | 9.2 | 0 | 3 | 1 | 1 | 3.0 | 0 |
| 18 |  | M. Mack | 174 | 9/8/2019 | IND | @ |  LAC | 25 | 7.0 | 1 | 0 | 0 | 0 | 0 | |
| 19 | | J. Jones | 174 | 9/7/1986 | DET | @ | MIN | 36 | 4.8 | 1 | 0 | 0 | 0 | ||
| 20 | | O.J. Simpson | 173 | 9/21/1975 | BUF | vs | NYJ | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |
| 21 |  | E. Smith | 171 | 9/4/1994 | DAL | @ |  PIT | 31 | 5.5 | 1 | 3 | 3 | 1.0 | 0 | |
| 22 |  | J. Brown | 171 | 9/28/1958 | CLE | @ | LA | 24 | 7.1 | 2 | |||||
| 23 | | C.J. Spiller | 169 | 9/9/2012 | BUF | @ | NYJ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 |
| 24 | | R. Smith | 169 | 8/31/1997 | MIN | @ | BUF | 16 | 10.6 | 1 | 5 | 1 | 5.0 | 0 | |
| 25 |  | C. Hyde | 168 | 9/14/2015 | SF | vs | MIN | 26 | 6.5 | 2 | 14 | 2 | 2 | 7.0 | 0 |
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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30.9
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OPP PPG
21.6
11th
RUSH YDS/G
131.2
9th
PASS YDS/G
231.6
17th
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