Since 2010, James Cook III has the most rushing yards for the Bills in a game, with 216 yards against the Panthers on October 26.
Interpreted as:
most rushing yards in a regular-season game by a bill since 2010| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 216 | 10/26/2025 |  BUF | @ |  CAR | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |
| 2 | | J. Cook III | 179 | 12/17/2023 | BUF | vs |  DAL | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 |
| 3 |  | C.J. Spiller | 169 | 9/9/2012 | BUF | @ |  NYJ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 |
| 4 |  | L. McCoy | 156 | 12/10/2017 | BUF | vs |  IND | 32 | 4.9 | 1 | 0 | 0 | 0 | 0 | |
| 5 | | L. McCoy | 153 | 12/18/2016 | BUF | vs |  CLE | 19 | 8.1 | 2 | 16 | 3 | 3 | 5.3 | 0 |
| 6 | | L. McCoy | 151 | 10/29/2017 | BUF | vs |  OAK | 27 | 5.6 | 1 | 22 | 6 | 7 | 3.7 | 0 |
| 7 | | L. McCoy | 150 | 10/9/2016 | BUF | @ |  LA | 18 | 8.3 | 0 | 8 | 2 | 2 | 4.0 | 0 |
| 8 | | C.J. Spiller | 149 | 12/1/2013 | BUF | vs |  ATL | 15 | 9.9 | 1 | 8 | 2 | 4 | 4.0 | 0 |
| 9 | | L. McCoy | 140 | 10/16/2016 | BUF | vs |  SF | 19 | 7.4 | 3 | 2 | 1 | 2 | 2.0 | 0 |
| 10 | | C.J. Spiller | 138 | 12/23/2012 | BUF | @ |  MIA | 22 | 6.3 | 0 | 35 | 4 | 5 | 8.8 | 0 |
| 11 |  | J. Allen | 135 | 12/2/2018 | BUF | @ | MIA | 9 | 15.0 | 0 | 0 | 0 | 0 | 0 | |
| 12 | | F. Jackson | 133 | 11/14/2010 | BUF | vs |  DET | 25 | 5.3 | 1 | 37 | 6 | 7 | 6.2 | 1 |
| 13 | | J. Cook III | 132 | 9/14/2025 | BUF | @ |  NYJ | 21 | 6.3 | 2 | 3 | 1 | 1 | 3.0 | 0 |
| 14 | | L. McCoy | 130 | 12/4/2016 | BUF | @ | OAK | 17 | 7.6 | 0 | 61 | 7 | 7 | 8.7 | 0 |
| 15 | | L. McCoy | 128 | 12/24/2016 | BUF | vs | MIA | 24 | 5.3 | 1 | 17 | 5 | 6 | 3.4 | 0 |
| 16 | | J. Cook III | 123 | 9/17/2023 | BUF | vs | LV | 17 | 7.2 | 0 | 36 | 4 | 4 | 9.0 | 0 |
| 17 | | C.J. Spiller | 123 | 9/16/2012 | BUF | vs |  KC | 15 | 8.2 | 2 | 47 | 3 | 3 | 15.7 | 0 |
| 18 | | F. Jackson | 121 | 10/16/2011 | BUF | @ |  NYG | 16 | 7.6 | 1 | 47 | 5 | 6 | 9.4 | 0 |
| 19 | | F. Jackson | 120 | 10/30/2011 | BUF | vs |  WAS | 26 | 4.6 | 0 | 74 | 3 | 4 | 24.7 | 0 |
| 20 | | J. Cook III | 117 | 9/28/2025 | BUF | vs |  NO | 22 | 5.3 | 1 | 18 | 3 | 4 | 6.0 | 0 |
| 21 | | F. Jackson | 117 | 9/18/2011 | BUF | vs | OAK | 15 | 7.8 | 2 | 23 | 2 | 2 | 11.5 | 0 |
| 22 | | C.J. Spiller | 116 | 11/3/2013 | BUF | vs | KC | 12 | 9.7 | 0 | 39 | 2 | 3 | 19.5 | 0 |
| 23 | | F. Jackson | 116 | 11/21/2010 | BUF | @ |  CIN | 21 | 5.5 | 2 | 13 | 3 | 5 | 4.3 | 0 |
| 24 | | J. Cook III | 114 | 11/2/2025 | BUF | vs | KC | 27 | 4.2 | 0 | 11 | 1 | 1 | 11.0 | 0 |
| 25 | | L. McCoy | 114 | 11/19/2017 | BUF | @ |  LAC | 13 | 8.8 | 1 | 12 | 1 | 1 | 12.0 | 1 |
More Bills Stats
Team Rankings
PPG
29.4
3rd
OPP PPG
20.9
9th
RUSH YDS/G
161.5
1st
PASS YDS/G
235.9
14th
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