Trey Sermon had his most rushing yards in a game against the Seahawks on October 3, 2021, with 89 yards.
Interpreted as:
most rushing yards in a regular-season game by Trey Sermon| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | T. Sermon | 89 | 10/3/2021 | vs | 19 | 4.7 | 0 | 0 | 0 | 0 | 0 | |||
| 2 | | T. Sermon | 88 | 12/16/2023 | vs | 17 | 5.2 | 0 | 0 | 0 | 0 | 0 | |||
| 3 | | T. Sermon | 38 | 10/6/2024 | @ | 10 | 3.8 | 1 | 25 | 6 | 6 | 4.2 | 0 | ||
| 4 | | T. Sermon | 36 | 10/20/2024 | vs | 8 | 4.5 | 0 | 13 | 1 | 1 | 13.0 | 0 | ||
| 5 | | T. Sermon | 32 | 12/31/2023 | vs | 5 | 6.4 | 0 | 9 | 2 | 2 | 4.5 | 0 | ||
| 6 | | T. Sermon | 32 | 11/21/2021 | @ | 10 | 3.2 | 0 | 23 | 1 | 1 | 23.0 | 0 | ||
| 7 | | T. Sermon | 31 | 9/26/2021 | vs | 10 | 3.1 | 1 | 3 | 2 | 3 | 1.5 | 0 | ||
| 8 | | T. Sermon | 29 | 10/13/2024 | @ | 18 | 1.6 | 0 | 0 | 0 | 0 | 0 | |||
| 9 | | T. Sermon | 25 | 12/22/2024 | vs | 8 | 3.1 | 0 | 0 | 0 | 0 | 0 | |||
| 10 | | T. Sermon | 19 | 10/2/2022 | vs | 2 | 9.5 | 0 | 0 | 0 | 0 | 0 | |||
| 11 | | T. Sermon | 17 | 9/24/2023 | @ | 5 | 3.4 | 0 | 4 | 1 | 2 | 4.0 | 0 | ||
| 12 | | T. Sermon | 16 | 9/22/2024 | vs | 2 | 8.0 | 1 | 0 | 0 | 0 | 0 | |||
| 13 | | T. Sermon | 13 | 12/10/2023 | @ | 3 | 4.3 | 0 | 0 | 0 | 0 | 0 | |||
| 14 | | T. Sermon | 8 | 9/29/2024 | vs | 5 | 1.6 | 0 | 0 | 0 | 0 | 0 | |||
| 15 | | T. Sermon | 8 | 9/19/2021 | @ | 1 | 8.0 | 0 | 0 | 0 | 0 | 0 | |||
| 16 | | T. Sermon | 7 | 10/1/2023 | vs | 3 | 2.3 | 0 | 0 | 0 | 0 | 0 | |||
| 17 | | T. Sermon | 7 | 10/10/2021 | @ | 1 | 7.0 | 0 | 0 | 0 | 0 | 0 | |||
| 18 | | T. Sermon | 4 | 11/3/2024 | @ | 2 | 2.0 | 0 | 9 | 1 | 2 | 9.0 | 0 | ||
| 19 | | T. Sermon | 3 | 12/15/2024 | @ | 1 | 3.0 | 0 | 9 | 2 | 2 | 4.5 | 0 | ||
| 20 | | T. Sermon | 3 | 12/24/2023 | @ | 2 | 1.5 | 0 | 0 | 0 | 0 | 0 |
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More 49ers Stats
Team Leaders 
PASS
2,167
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RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
