The Buffalo Bills had their most rushing yards in a game against the Giants on November 26, 1978, with 366 yards.
Interpreted as:
most rushing yards in a regular-season game running back buffalo bills| TEAM | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 366 | 11/26/1978 |  BUF | vs |  NYG | 48 | 7.6 | 5 | 7 | 2 | 3.5 | 0 | |
| 2 | | Bills | 355 | 9/16/1973 | BUF | @ |  NE | 47 | 7.6 | 4 | 38 | 2 | 19.0 | 0 | |
| 3 | | Bills | 318 | 11/22/1992 | BUF | vs |  ATL | 41 | 7.8 | 3 | 21 | 2 | 10.5 | 0 | |
| 4 | | Bills | 309 | 9/28/1975 | BUF | @ |  PIT | 44 | 7.0 | 1 | 2 | 1 | 2.0 | 0 | |
| 5 | | Bills | 306 | 12/14/1975 | BUF | @ | NE | 48 | 6.4 | 3 | 35 | 3 | 11.7 | 0 | |
| 6 | | Bills | 304 | 12/16/1973 | BUF | @ |  NYJ | 60 | 5.1 | 3 | 15 | 1 | 15.0 | 0 | |
| 7 | | Bills | 302 | 9/21/1975 | BUF | vs | NYJ | 61 | 5.0 | 2 | 8 | 2 | 4.0 | 1 | |
| 8 | | Bills | 294 | 11/25/1976 | BUF | @ |  DET | 38 | 7.7 | 2 | 7 | 1 | 7.0 | 0 | |
| 9 | | Bills | 291 | 12/9/1973 | BUF | vs | NE | 38 | 7.7 | 1 | 0 | 0 | 0 | ||
| 10 | | Bills | 290 | 9/24/1990 | BUF | @ | NYJ | 34 | 8.5 | 1 | 37 | 7 | 5.3 | 0 | |
| 11 | | Bills | 287 | 10/13/1962 | BUF | vs |  SD | 43 | 6.7 | 2 | 23 | 2 | 11.5 | 1 | |
| 12 | | Bills | 282 | 12/8/1963 | BUF | vs | NYJ | 41 | 6.9 | 5 | -1 | 2 | -0.5 | 0 | |
| 13 | | Bills | 280 | 10/29/1989 | BUF | vs |  MIA | 51 | 5.5 | 2 | 21 | 2 | 10.5 | 0 | |
| 14 | | Bills | 273 | 10/13/1991 | BUF | vs |  IND | 36 | 7.6 | 4 | 30 | 2 | 15.0 | 0 | |
| 15 | | Bills | 266 | 10/5/1975 | BUF | vs |  DEN | 53 | 5.0 | 3 | 19 | 1 | 19.0 | 1 | |
| 16 | | Bills | 255 | 12/11/1988 | BUF | vs |  RAI | 47 | 5.4 | 3 | 9 | 1 | 9.0 | 0 | |
| 17 | | Bills | 245 | 11/27/1975 | BUF | @ |  STL | 57 | 4.3 | 4 | 33 | 3 | 11.0 | 0 | |
| 18 | | Bills | 244 | 12/17/2023 | BUF | vs |  DAL | 39 | 6.3 | 2 | 46 | 3 | 4 | 15.3 | 1 |
| 19 | | Bills | 244 | 1/3/2010 | BUF | vs | IND | 38 | 6.4 | 0 | 17 | 3 | 4 | 5.7 | 1 |
| 20 | | Bills | 244 | 11/3/1996 | BUF | vs |  WAS | 46 | 5.3 | 4 | 20 | 4 | 5.0 | 0 | |
| 21 | | Bills | 244 | 10/3/1976 | BUF | vs |  KC | 41 | 6.0 | 3 | 20 | 3 | 6.7 | 0 | |
| 22 | | Bills | 241 | 11/8/1987 | BUF | vs | DEN | 52 | 4.6 | 1 | 41 | 5 | 8.2 | 0 | |
| 23 | | Bills | 241 | 12/5/1976 | BUF | @ | MIA | 37 | 6.5 | 1 | 38 | 5 | 7.6 | 0 | |
| 24 | | Bills | 239 | 11/18/1973 | BUF | vs | MIA | 37 | 6.5 | 0 | 38 | 2 | 19.0 | 0 | |
| 25 | | Bills | 238 | 10/26/2025 | BUF | @ |  CAR | 32 | 7.4 | 2 | 0 | 0 | 1 | 0 | |
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More Bills Stats
Team Rankings
PPG
29.4
4th
OPP PPG
20.9
9th
RUSH YDS/G
161.5
1st
PASS YDS/G
235.9
14th
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