O.J. Simpson has averaged the most rushing yards per game by a running back in a season, with 143.1 per game in 1973.
| NAME | RUSH YDS/G | SEASON | TM | GP | RUSH YDS | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 143.1 | 1973 |  BUF | 14 | 2,003 | 332 | 6.0 | 12 | 70 | 6 | 11.7 | 5.0 | 0 | |
| 2 |  | J. Brown | 133.1 | 1963 |  CLE | 14 | 1,863 | 291 | 6.4 | 12 | 268 | 24 | 11.2 | 19.1 | 3 | |
| 3 |  | W. Payton | 132.3 | 1977 |  CHI | 14 | 1,852 | 339 | 5.5 | 14 | 269 | 27 | 10.0 | 19.2 | 2 | |
| 4 |  | E. Dickerson | 131.6 | 1984 |  RAM | 16 | 2,105 | 379 | 5.6 | 14 | 139 | 21 | 6.6 | 8.7 | 0 | |
| 5 |  | A. Peterson | 131.1 | 2012 |  MIN | 16 | 2,097 | 348 | 6.0 | 12 | 217 | 40 | 51 | 5.4 | 13.6 | 1 |
| 6 | | O.J. Simpson | 129.8 | 1975 | BUF | 14 | 1,817 | 329 | 5.5 | 16 | 426 | 28 | 15.2 | 30.4 | 7 | |
| 7 |  | J. Lewis | 129.1 | 2003 |  BAL | 16 | 2,066 | 387 | 5.3 | 14 | 205 | 26 | 38 | 7.9 | 12.8 | 0 |
| 8 | | E. Campbell | 128.9 | 1980 |  HOU | 15 | 1,934 | 373 | 5.2 | 13 | 47 | 11 | 4.3 | 3.1 | 0 | |
| 9 |  | B. Sanders | 128.3 | 1997 |  DET | 16 | 2,053 | 335 | 6.1 | 11 | 305 | 33 | 9.2 | 19.1 | 3 | |
| 10 | | J. Brown | 127.3 | 1958 | CLE | 12 | 1,527 | 257 | 5.9 | 17 | 138 | 16 | 8.6 | 11.5 | 1 | |
| 11 |  | D. Henry | 126.7 | 2020 |  TEN | 16 | 2,027 | 378 | 5.4 | 17 | 114 | 19 | 31 | 6.0 | 7.1 | 0 |
| 12 | | T. Davis | 125.5 | 1998 |  DEN | 16 | 2,008 | 392 | 5.1 | 21 | 217 | 25 | 8.7 | 13.6 | 2 | |
| 13 |  | C. Johnson | 125.4 | 2009 | TEN | 16 | 2,006 | 358 | 5.6 | 14 | 503 | 50 | 71 | 10.1 | 31.4 | 2 |
| 14 |  | S. Barkley | 125.3 | 2024 |  PHI | 16 | 2,005 | 345 | 5.8 | 13 | 278 | 33 | 43 | 8.4 | 17.4 | 2 |
| 15 | | C. Portis | 122.4 | 2003 | DEN | 13 | 1,591 | 290 | 5.5 | 14 | 314 | 38 | 51 | 8.3 | 24.2 | 0 |
| 16 | | G. Hill | 120.0 | 1998 |  STL | 2 | 240 | 40 | 6.0 | 4 | 6 | 1 | 6.0 | 3.0 | 0 | |
| 17 | | A. Green | 117.7 | 2003 |  GB | 16 | 1,883 | 355 | 5.3 | 15 | 367 | 50 | 60 | 7.3 | 22.9 | 5 |
| 18 | | B. Sanders | 117.7 | 1994 | DET | 16 | 1,883 | 331 | 5.7 | 7 | 283 | 44 | 6.4 | 17.7 | 1 | |
| 19 | | S. Alexander | 117.5 | 2005 |  SEA | 16 | 1,880 | 370 | 5.1 | 27 | 78 | 15 | 29 | 5.2 | 4.9 | 1 |
| 20 | | D. Henry | 117.1 | 2021 | TEN | 8 | 937 | 219 | 4.3 | 10 | 154 | 18 | 20 | 8.6 | 19.3 | 0 |
| 21 | | T. Davis | 116.7 | 1997 | DEN | 15 | 1,750 | 369 | 4.7 | 15 | 287 | 42 | 6.8 | 19.1 | 0 | |
| 22 | | T. Barber | 116.3 | 2005 |  NYG | 16 | 1,860 | 357 | 5.2 | 9 | 530 | 54 | 70 | 9.8 | 33.1 | 2 |
| 23 | | R. Williams | 115.8 | 2002 |  MIA | 16 | 1,853 | 383 | 4.8 | 16 | 363 | 47 | 59 | 7.7 | 22.7 | 1 |
| 24 | | J. Anderson | 115.4 | 1998 |  ATL | 16 | 1,846 | 410 | 4.5 | 14 | 319 | 27 | 11.8 | 19.9 | 2 | |
| 25 | | P. Holmes | 115.4 | 2002 |  KC | 14 | 1,615 | 313 | 5.2 | 21 | 672 | 70 | 81 | 9.6 | 48.0 | 3 |
StatMuse has season-level data for rushing yards per game going back to the 1932 season.
More Bills Stats
Team Leaders 
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3,276
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RUSH
1,415
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REC
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Team Rankings
PPG
29.4
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OPP PPG
23.1
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RUSH YDS/G
158.5
1st
PASS YDS/G
237.9
11th
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