Adrian Clayborn, Osi Umenyiora and Fred Dean are tied for the most sacks by a defensive lineman in a game, with 6 sacks.

most sacks in a game by a defensive end
Interpreted as:
most defensive sacks in a regular-season game by a defensive end
11/12/2017Clayborn9/30/2007Umenyiora11/13/1983Dean9/4/1983Gay12/13/2015Mack9/20/2009Odom12/22/2002Holliday10/12/1997Smith9/18/1988Jeter11/16/1986O'Neal11/10/1985Jeffcoat9/16/1984Holloway10/2/1983Long9/15/2013Williams9/30/2012Wake10/5/2009Allen10/18/1998Douglas9/15/1991Simmons12/27/1987Dent11/25/1984Cooks11/4/1984Dent12/18/1983Greer10/11/2020Donald6.06.06.05.55.05.05.05.05.05.05.05.05.04.54.54.54.54.54.54.54.54.54.0
StatMuse has game-level data for sacks going back to the 1982 season.

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