5 players are tied for the most tackles for loss in a game, with 6 tackles. The first three are Joey Bosa on November 29, 2020, Aaron Donald on October 21, 2018 and J.J. Watt on September 13, 2015 and on December 16, 2012.

Interpreted as:

most tfls by a player in a single regular-season game

	NAME	TFL	DATE	TM		OPP	TKL	AST	COMB	SCK	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Joey Bosa J. Bosa	6	11/29/2020	LAC	@	BUF	8	1	9	3.0	17	0	0	0	0	1	0
2	Aaron Donald A. Donald	6	10/21/2018	LAR	@	SF	8	1	9	4.0	29	0	0	0	1	1	0
3	J.J. Watt	6	9/13/2015	HOU	vs	KC	9	0	9	2.0	10	0	0	0	0	0	0
4	J.J. Watt	6	12/16/2012	HOU	vs	IND	10	0	10	3.0	22	0	0	0	1	0	0
5	Andre Carter A. Carter	6	12/13/2009	WAS	@	OAK	7	0	7	2.0	8	0	0	0	0	0	0
6	Jeremiah Trotter J. Trotter	6	12/30/2001	PHI	vs	NYG	12	3	15	1.0	9	0	0	0	0	0	0
7	Maxx Crosby M. Crosby	5	11/23/2025	LV	vs	CLE	5	3	8	0.0	0	0	0	0	0	0	0
8	Myles Garrett M. Garrett	5	11/16/2025	CLE	vs	BAL	5	0	5	4.0	17	0	0	0	0	0	0
9	Myles Garrett M. Garrett	5	10/26/2025	CLE	@	NE	6	0	6	5.0	33	0	0	0	1	0	0
10	Tuli Tuipulotu T. Tuipulotu	5	9/28/2025	LAC	@	NYG	7	3	10	4.0	19	0	0	0	1	0	0
11	Quincy Williams Q. Williams	5	1/5/2025	NYJ	vs	MIA	7	2	9	0.0	0	0	0	0	1	1	0
12	Micah McFadden M. McFadden	5	12/8/2024	NYG	vs	NO	8	3	11	0.0	0	0	0	0	0	0	0
13	Danielle Hunter D. Hunter	5	11/24/2024	HOU	vs	TEN	6	1	7	3.0	18	0	0	0	0	0	0
14	Khalil Mack K. Mack	5	10/1/2023	LAC	vs	LV	8	2	10	6.0	45	0	0	0	2	0	0
15	Kyle Van Noy K. Van Noy	5	12/6/2020	MIA	vs	CIN	8	0	8	3.0	18	0	0	0	0	0	0
16	Za'Darius Smith Z. Smith	5	12/23/2019	GB	@	MIN	6	1	7	3.5	32	0	0	0	0	0	0
17	Akiem Hicks A. Hicks	5	11/18/2018	CHI	vs	MIN	6	0	6	1.0	8	0	0	0	0	0	0
18	Shaquille Leonard S. Leonard	5	9/23/2018	IND	@	PHI	9	4	13	2.0	19	0	0	0	0	0	0
19	Chandler Jones C. Jones	5	11/26/2017	ARI	vs	JAX	6	0	6	2.0	20	0	0	0	0	0	0
20	Khalil Mack K. Mack	5	12/13/2015	OAK	@	DEN	6	1	7	5.0	32	0	0	0	1	0	0
21	J.J. Watt	5	11/22/2015	HOU	vs	NYJ	8	0	8	2.0	14	0	0	0	0	0	0
22	J.J. Watt	5	12/29/2013	HOU	@	TEN	9	0	9	1.0	6	0	0	0	1	0	0
23	A.J. Hawk	5	10/13/2013	GB	@	BAL	8	2	10	3.0	18	0	0	0	0	0	0
24	Von Miller V. Miller	5	10/7/2012	DEN	@	NE	7	1	8	2.0	7	0	0	0	1	0	0
25	Da'Quan Bowers D. Bowers	5	12/4/2011	TB	vs	CAR	7	1	8	1.5	7.5	0	0	0	0	0	0

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StatMuse has game-level data for tackles for loss going back to the 2001 season.

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5 players are tied for the most tackles for loss in a game, with 6 tackles. The first three are Joey Bosa on November 29, 2020, Aaron Donald on October 21, 2018 and J.J. Watt on September 13, 2015 and on December 16, 2012.

Interpreted as:

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