O.J. Simpson has gained the most all-purpose yards for the Bills in a game, with 303 yards against the Jets on October 4, 1970.
Interpreted as:
most total yards by player in a bills regular-season game| NAME | YDS | DATE | TM | OPP | TD | RUSH YDS | RUSH TD | REC YDS | REC TD | KR YDS | KR TD | PR YDS | PR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 303 | 10/4/1970 | vs | 2 | 99 | 1 | 63 | 0 | 141 | 1 | 0 | 0 | ||
| 2 | | O.J. Simpson | 273 | 11/25/1976 | @ | 2 | 273 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 3 |  | T. Thomas | 268 | 9/1/1991 | vs | 2 | 165 | 1 | 103 | 1 | 0 | 0 | 0 | 0 | ||
| 4 | | J. Butler | 267 | 9/23/1979 | vs | 4 | 12 | 0 | 255 | 4 | 0 | 0 | 0 | 0 | ||
| 5 | | T. McGee | 266 | 12/24/2005 | @ | 2 | 0 | 0 | 0 | 0 | 220 | 1 | 0 | 0 | ||
| 6 | | L. Evans | 265 | 11/19/2006 | @ | 2 | 0 | 0 | 265 | 2 | 0 | 0 | 0 | 0 | ||
| 7 | | F. Jackson | 263 | 11/15/2009 | @ | 0 | 48 | 0 | 23 | 0 | 167 | 0 | 25 | 0 | ||
| 8 | | C. Gilchrist | 255 | 9/15/1962 | vs | 2 | 131 | 1 | 48 | 1 | 76 | 0 | 0 | 0 | ||
| 9 | | O.J. Simpson | 250 | 9/16/1973 | @ | 2 | 250 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 10 | | J. Cribbs | 248 | 11/1/1981 | vs | 3 | 85 | 0 | 163 | 3 | 0 | 0 | 0 | 0 | ||
| 11 | | C. Gilchrist | 243 | 12/8/1963 | vs | 5 | 243 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 12 | | N. Miller-Hines | 241 | 1/8/2023 | vs | 2 | 0 | 0 | 0 | 0 | 235 | 2 | 6 | 0 | ||
| 13 | | F. Jackson | 241 | 1/3/2010 | vs | 1 | 212 | 0 | 15 | 1 | 14 | 0 | 0 | 0 | ||
| 14 | | C. Rogers | 237 | 9/15/2002 | @ | 1 | 0 | 0 | 0 | 0 | 221 | 1 | 16 | 0 | ||
| 15 | | D. Holmes | 231 | 10/23/1995 | @ | 0 | 40 | 0 | 80 | 0 | 111 | 0 | 0 | 0 | ||
| 16 | | G. Bass | 231 | 11/8/1964 | @ | 1 | 0 | 0 | 231 | 1 | 0 | 0 | 0 | 0 | ||
| 17 | | C.J. Spiller | 228 | 9/26/2010 | @ | 2 | 29 | 0 | 10 | 1 | 189 | 1 | 0 | 0 | ||
| 18 | | O.J. Simpson | 227 | 9/28/1975 | @ | 1 | 227 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 19 | | O.J. Simpson | 226 | 11/16/1969 | vs | 2 | 72 | 0 | 81 | 2 | 73 | 0 | 0 | 0 | ||
| 20 |  | J. Cook III | 221 | 12/17/2023 | vs | 2 | 179 | 1 | 42 | 1 | 0 | 0 | 0 | 0 | ||
| 21 | | F. Jackson | 220 | 12/20/2009 | vs | 0 | 80 | 0 | 32 | 0 | 108 | 0 | 0 | 0 | ||
| 22 | | J. Lofton | 220 | 10/21/1991 | vs | 2 | 0 | 0 | 220 | 2 | 0 | 0 | 0 | 0 | ||
| 23 | | T. Thomas | 219 | 9/24/1990 | @ | 0 | 214 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | ||
| 24 | | O.J. Simpson | 219 | 12/9/1973 | vs | 1 | 219 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 25 | | G. Bell | 218 | 11/18/1984 | vs | 2 | 206 | 1 | 12 | 1 | 0 | 0 | 0 | 0 | ||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |