The San Francisco 49ers were 2-2 against the spread in the NFC in Week 2 against the AFC from 2002 through 2021.
| TEAM | ATS | ATS COV % | ATS AVG | O/U REC | O/U AVG | GP | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 2-2 | 50 | +0.9 | 3-1 | +5.8 | 4 | 2 | 2 | 0 | 13 | 104 | 26.0 | 97 | 24.3 | 89 | 51.9 | 60.0 |
| 2 |  | Cowboys | 6-1 | 85.7 | +3.7 | 2-5 | -3.1 | 7 | 5 | 2 | 0 | 16 | 156 | 22.3 | 131 | 18.7 | 140 | 37.8 | 50.0 |
| 3 |  | Buccaneers | 2-1 | 66.7 | +8.7 | 1-2 | -3 | 3 | 2 | 1 | 0 | 7 | 64 | 21.3 | 36 | 12.0 | 54 | 38.6 | 75.0 |
| 4 |  | Eagles | 1-4 | 20 | -6.9 | 5-0 | +4.3 | 5 | 2 | 3 | 0 | 12 | 114 | 22.8 | 141 | 28.2 | 122 | 41.8 | 100.0 |
| 5 |  | Saints | 1-4 | 20 | -5 | 4-1 | +0.1 | 5 | 2 | 3 | 0 | 14 | 120 | 24.0 | 124 | 24.8 | 102 | 44.6 | 50.0 |
| 6 |  | Cardinals | 4-2 | 66.7 | +7.6 | 2-4 | -5.2 | 6 | 4 | 2 | 0 | 13 | 127 | 21.2 | 104 | 17.3 | 106 | 31.9 | 50.0 |
| 7 |  | Lions | 3-1 | 75 | +10.8 | 2-2 | -8.5 | 4 | 3 | 1 | 0 | 13 | 104 | 26.0 | 45 | 11.3 | 82 | 42.3 | 100.0 |
| 8 |  | Panthers | 3-3 | 50 | +1.8 | 3-2-1 | -2.1 | 6 | 4 | 2 | 0 | 15 | 132 | 22.0 | 112 | 18.7 | 126 | 41.9 | |
| 9 |  | Packers | 1-2-1 | 25 | -2.1 | 3-1 | +7 | 4 | 2 | 2 | 0 | 13 | 113 | 28.3 | 88 | 22.0 | 92 | 56.6 | |
| 10 |  | Bears | 2-2 | 50 | +1.1 | 0-4 | -7.3 | 4 | 4 | 0 | 0 | 7 | 73 | 18.3 | 55 | 13.8 | 69 | 35.8 | 50.0 |
| 11 |  | Falcons | 3-1 | 75 | +2.4 | 1-2-1 | -3.5 | 4 | 2 | 2 | 0 | 9 | 79 | 19.8 | 86 | 21.5 | 81 | 40.8 | 50.0 |
| 12 |  | Redskins | 1-2 | 33.3 | +2.5 | 2-1 | +1.3 | 3 | 1 | 2 | 0 | 8 | 77 | 25.7 | 61 | 20.3 | 73 | 33.3 | 50.0 |
| 13 |  | Rams | 1-1 | 50 | +0.3 | 1-1 | -2 | 2 | 1 | 1 | 0 | 5 | 41 | 20.5 | 40 | 20.0 | 37 | 26.3 | 0.0 |
| 14 |  | Seahawks | 2-4 | 33.3 | -6.6 | 5-1 | +4.9 | 6 | 2 | 4 | 0 | 18 | 128 | 21.3 | 174 | 29.0 | 103 | 38.1 | 50.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
1,007
Purdy
RUSH
218
McCaffrey
REC
244
Kittle
Team Rankings
PPG
30.5
2nd
OPP PPG
16.0
3rd
RUSH YDS/G
137.3
6th
PASS YDS/G
251.8
13th
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DAL
NFL 2026 Leaders
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
| NFC North | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| NFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 |
Giants
Eagles
Vikings
Bears
Lions
Packers
Panthers
Saints
Buccaneers| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| AFC South | W | L | T | PCT |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 | |
0 | 4 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 |
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