The San Francisco 49ers had a record of 2-2 against the spread in the NFC against the AFC in Week 2 between the 2002 and 2021 seasons.
Interpreted as:
nfc ats vs afc week 2 or more 2002 to 2021| TEAM | ATS | ATS COV % | ATS AVG | O/U REC | O/U AVG | GP | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 2-2 | 50 | +0.9 | 3-1 | +5.8 | 4 | 2 | 2 | 0 | 13 | 104 | 26.0 | 97 | 24.3 | 89 | 51.9 | 60.0 |
| 2 |  | Cowboys | 6-1 | 85.7 | +3.7 | 2-5 | -3.1 | 7 | 5 | 2 | 0 | 16 | 156 | 22.3 | 131 | 18.7 | 141 | 37.8 | 50.0 |
| 3 |  | Buccaneers | 2-1 | 66.7 | +8.7 | 1-2 | -3 | 3 | 2 | 1 | 0 | 7 | 64 | 21.3 | 36 | 12.0 | 54 | 38.6 | 75.0 |
| 4 |  | Eagles | 1-4 | 20 | -6.9 | 5-0 | +4.3 | 5 | 2 | 3 | 0 | 12 | 114 | 22.8 | 141 | 28.2 | 122 | 41.8 | 100.0 |
| 5 |  | Saints | 1-4 | 20 | -5 | 4-1 | +0.1 | 5 | 2 | 3 | 0 | 14 | 120 | 24.0 | 124 | 24.8 | 102 | 44.6 | 50.0 |
| 6 |  | Cardinals | 4-2 | 66.7 | +7.6 | 2-4 | -5.2 | 6 | 4 | 2 | 0 | 13 | 127 | 21.2 | 104 | 17.3 | 106 | 31.9 | 50.0 |
| 7 |  | Lions | 3-1 | 75 | +10.8 | 2-2 | -8.5 | 4 | 3 | 1 | 0 | 13 | 104 | 26.0 | 45 | 11.3 | 82 | 42.3 | 100.0 |
| 8 |  | Panthers | 3-3 | 50 | +1.8 | 3-2-1 | -2.1 | 6 | 4 | 2 | 0 | 15 | 132 | 22.0 | 112 | 18.7 | 126 | 41.9 | |
| 9 |  | Packers | 1-2-1 | 25 | -2.1 | 3-1 | +7 | 4 | 2 | 2 | 0 | 13 | 113 | 28.3 | 88 | 22.0 | 92 | 56.6 | |
| 10 |  | Bears | 2-2 | 50 | +1.1 | 0-4 | -7.3 | 4 | 4 | 0 | 0 | 7 | 73 | 18.3 | 55 | 13.8 | 69 | 35.8 | 50.0 |
| 11 |  | Falcons | 3-1 | 75 | +2.4 | 1-2-1 | -3.5 | 4 | 2 | 2 | 0 | 9 | 79 | 19.8 | 86 | 21.5 | 81 | 40.8 | 50.0 |
| 12 |  | Redskins | 1-2 | 33.3 | +2.5 | 2-1 | +1.3 | 3 | 1 | 2 | 0 | 8 | 77 | 25.7 | 61 | 20.3 | 73 | 33.3 | 50.0 |
| 13 |  | Rams | 1-1 | 50 | +0.3 | 1-1 | -2 | 2 | 1 | 1 | 0 | 5 | 41 | 20.5 | 40 | 20.0 | 37 | 26.3 | 0.0 |
| 14 |  | Seahawks | 2-4 | 33.3 | -6.6 | 5-1 | +4.9 | 6 | 2 | 4 | 0 | 18 | 128 | 21.3 | 174 | 29.0 | 103 | 38.1 | 50.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
