The Buffalo Bills had the highest point differential by a team in a Week-2 game in 2021, with a 35-point differential against the Dolphins on September 19, 2021.
| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 35 | 9/19/2021 | @ | W 35-0 | 5 | 21 | 314 | 216 | 53.8 | 100.0 | ||
| 2 |  | Buccaneers | 23 | 9/19/2021 | vs | W 48-25 | 7 | 21 | 341 | 348 | 33.3 | 50.0 | ||
| 3 |  | Patriots | 19 | 9/19/2021 | @ | W 25-6 | 2 | 17 | 260 | 336 | 25.0 | |||
| 4 |  | Panthers | 19 | 9/19/2021 | vs | W 26-7 | 3 | 28 | 383 | 128 | 53.3 | |||
| 5 |  | Packers | 18 | 9/20/2021 | vs | W 35-17 | 5 | 25 | 323 | 344 | 55.6 | |||
| 6 |  | Browns | 10 | 9/19/2021 | vs | W 31-21 | 4 | 22 | 355 | 302 | 44.4 | |||
| 7 |  | Broncos | 10 | 9/19/2021 | @ | W 23-13 | 2 | 22 | 398 | 189 | 18.2 | 100.0 | ||
| 8 |  | Raiders | 9 | 9/19/2021 | @ | W 26-17 | 2 | 22 | 425 | 331 | 38.5 | 100.0 | ||
| 9 |  | 49ers | 6 | 9/19/2021 | @ | W 17-11 | 2 | 23 | 306 | 328 | 42.9 | 100.0 | ||
| 10 |  | Bears | 3 | 9/19/2021 | vs | W 20-17 | 2 | 16 | 206 | 248 | 40.0 | 0.0 | ||
| 11 |  | Rams | 3 | 9/19/2021 | @ | W 27-24 | 3 | 21 | 371 | 354 | 33.3 | 0.0 | ||
| 12 |  | Cowboys | 3 | 9/19/2021 | @ | W 20-17 | 2 | 25 | 419 | 408 | 60.0 | 0.0 | ||
| 13 |  | Titans | 3 | 9/19/2021 | @ | W 33-30 | 3 | 33 | 532 | 397 | 42.9 | 0.0 | ||
| 14 |  | Cardinals | 1 | 9/19/2021 | vs | W 34-33 | 4 | 21 | 474 | 419 | 33.3 | 100.0 | ||
| 15 |  | Ravens | 1 | 9/19/2021 | vs | W 36-35 | 5 | 31 | 481 | 405 | 54.5 | 100.0 | ||
| 16 |  | Washington Football Team | 1 | 9/16/2021 | vs | W 30-29 | 3 | 25 | 407 | 391 | 30.8 | 100.0 | ||
| 17 |  | Vikings | -1 | 9/19/2021 | @ | L 33-34 | 4 | 22 | 419 | 474 | 20.0 | |||
| 18 |  | Chiefs | -1 | 9/19/2021 | @ | L 35-36 | 5 | 22 | 405 | 481 | 16.7 | |||
| 19 |  | Giants | -1 | 9/16/2021 | @ | L 29-30 | 2 | 21 | 391 | 407 | 33.3 | |||
| 20 |  | Bengals | -3 | 9/19/2021 | @ | L 17-20 | 2 | 14 | 248 | 206 | 46.2 | 0.0 | ||
| 21 |  | Colts | -3 | 9/19/2021 | vs | L 24-27 | 2 | 22 | 354 | 371 | 45.5 | 0.0 | ||
| 22 |  | Chargers | -3 | 9/19/2021 | vs | L 17-20 | 1 | 24 | 408 | 419 | 41.7 | 100.0 | ||
| 23 |  | Seahawks | -3 | 9/19/2021 | vs | L 30-33 | 4 | 17 | 397 | 532 | 33.3 | |||
| 24 |  | Eagles | -6 | 9/19/2021 | vs | L 11-17 | 1 | 18 | 328 | 306 | 41.7 | 0.0 | ||
| 25 |  | Steelers | -9 | 9/19/2021 | vs | L 17-26 | 2 | 17 | 331 | 425 | 41.7 | 0.0 | ||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |