The Buffalo Bills had the highest point differential per game played by a team in wins in 2021, with 22.09.
| TEAM | DIFF/GP | W | DIFF | GP | SEASON | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 22.09 | 11 | 243 | 11 | 2021 | 0 | 0 | 47 | 378 | 34.4 | 135 | 12.3 | 269 | 50.7 | 61.5 |
| 2 |  | Patriots | 21.4 | 10 | 214 | 10 | 2021 | 0 | 0 | 35 | 325 | 32.5 | 111 | 11.1 | 224 | 46.3 | 60.0 |
| 3 |  | Cowboys | 17 | 12 | 204 | 12 | 2021 | 0 | 0 | 52 | 421 | 35.1 | 217 | 18.1 | 288 | 46.5 | 64.7 |
| 4 |  | Eagles | 16.44 | 9 | 148 | 9 | 2021 | 0 | 0 | 30 | 281 | 31.2 | 133 | 14.8 | 193 | 45.5 | 40.0 |
| 5 |  | Broncos | 16.29 | 7 | 114 | 7 | 2021 | 0 | 0 | 21 | 189 | 27.0 | 75 | 10.7 | 157 | 50.0 | 100.0 |
| 6 |  | Colts | 16 | 9 | 144 | 9 | 2021 | 0 | 0 | 33 | 277 | 30.8 | 133 | 14.8 | 184 | 43.0 | 72.7 |
| 7 |  | Buccaneers | 15.08 | 13 | 196 | 13 | 2021 | 0 | 0 | 54 | 441 | 33.9 | 245 | 18.8 | 330 | 48.2 | 60.0 |
| 8 |  | Bengals | 14.5 | 10 | 145 | 10 | 2021 | 0 | 0 | 36 | 313 | 31.3 | 168 | 16.8 | 208 | 40.8 | 81.8 |
| 9 |  | Seahawks | 14.29 | 7 | 100 | 7 | 2021 | 0 | 0 | 31 | 239 | 34.1 | 139 | 19.9 | 138 | 44.4 | 100.0 |
| 10 |  | Chiefs | 14 | 12 | 168 | 12 | 2021 | 0 | 0 | 43 | 367 | 30.6 | 199 | 16.6 | 290 | 54.8 | 70.0 |
| 11 |  | Panthers | 13.8 | 5 | 69 | 5 | 2021 | 0 | 0 | 12 | 122 | 24.4 | 53 | 10.6 | 119 | 47.2 | 0.0 |
| 12 |  | Cardinals | 13.55 | 11 | 149 | 11 | 2021 | 0 | 0 | 40 | 337 | 30.6 | 188 | 17.1 | 249 | 45.3 | 83.3 |
| 13 |  | Saints | 13.44 | 9 | 121 | 9 | 2021 | 0 | 0 | 26 | 235 | 26.1 | 114 | 12.7 | 175 | 36.4 | 80.0 |
| 14 |  | Texans | 12.75 | 4 | 51 | 4 | 2021 | 0 | 0 | 14 | 130 | 32.5 | 79 | 19.8 | 76 | 53.6 | 100.0 |
| 15 |  | Rams | 12.42 | 12 | 149 | 12 | 2021 | 0 | 0 | 42 | 362 | 30.2 | 213 | 17.8 | 259 | 45.3 | 63.6 |
| 16 |  | 49ers | 11.4 | 10 | 114 | 10 | 2021 | 0 | 0 | 33 | 293 | 29.3 | 179 | 17.9 | 219 | 46.0 | 57.1 |
| 17 |  | Titans | 10.92 | 12 | 131 | 12 | 2021 | 0 | 0 | 40 | 343 | 28.6 | 212 | 17.7 | 249 | 46.5 | 88.9 |
| 18 |  | Dolphins | 10.56 | 9 | 95 | 9 | 2021 | 0 | 0 | 25 | 217 | 24.1 | 122 | 13.6 | 178 | 42.4 | 66.7 |
| 19 |  | Giants | 10.25 | 4 | 41 | 4 | 2021 | 0 | 0 | 8 | 88 | 22.0 | 47 | 11.8 | 75 | 39.2 | 50.0 |
| 20 |  | Chargers | 10.22 | 9 | 92 | 9 | 2021 | 0 | 0 | 38 | 305 | 33.9 | 213 | 23.7 | 226 | 50.4 | 71.4 |
| 21 |  | Packers | 10 | 13 | 130 | 13 | 2021 | 0 | 0 | 45 | 379 | 29.2 | 249 | 19.2 | 299 | 45.2 | 57.1 |
| 22 |  | Browns | 9.38 | 8 | 75 | 8 | 2021 | 0 | 0 | 22 | 187 | 23.4 | 112 | 14.0 | 171 | 45.3 | 33.3 |
| 23 |  | Lions | 9 | 3 | 27 | 3 | 2021 | 0 | 0 | 10 | 96 | 32.0 | 69 | 23.0 | 64 | 34.3 | 57.1 |
| 24 |  | Bears | 8.83 | 6 | 53 | 6 | 2021 | 0 | 0 | 14 | 134 | 22.3 | 81 | 13.5 | 119 | 39.2 | 50.0 |
| 25 |  | Ravens | 8.13 | 8 | 65 | 8 | 2021 | 0 | 0 | 22 | 209 | 26.1 | 144 | 18.0 | 204 | 41.7 | 100.0 |
More NFL News
Vikings add assistant GMs Trent Kirchner from Seahawks and Andrew Healy from Browns
Parents of former NFL player Doug Martin allege excessive police force led to his wrongful death
Detroit Lions player Terrion Arnold is charged with directing attack against 3 people in Florida
Brandon Aiyuk says he will sign with the Commanders if the 49ers grant his wish for a release
The Jaguars lock up breakout tight end Brenton Strange with a new contract extension
Former Buffalo Bills quarterback Jim Kelly says he was hospitalized after a stroke in the spring
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |