O.J. Simpson rushed for the most yards in 1972, with 1,251 yards.

	NAME	RUSH YDS	SEASON	TM	GP	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	AVG	REC YDS/G	REC TD
1	O.J. Simpson	1,251	1972	BUF	14	292	4.3	89.4	6	198	27	7.3	14.1	0
2	Larry Brown L. Brown	1,216	1972	WAS	12	285	4.3	101.3	8	473	32	14.8	39.4	4
3	Ron Johnson R. Johnson	1,182	1972	NYG	14	298	4.0	84.4	9	451	45	10.0	32.2	5
4	Larry Csonka L. Csonka	1,117	1972	MIA	14	213	5.2	79.8	6	48	5	9.6	3.4	0
5	Marv Hubbard M. Hubbard	1,100	1972	OAK	14	219	5.0	78.6	4	103	22	4.7	7.4	0
6	Franco Harris F. Harris	1,055	1972	PIT	14	188	5.6	75.4	10	180	21	8.6	12.9	1
7	Calvin Hill C. Hill	1,036	1972	DAL	14	245	4.2	74.0	6	364	43	8.5	26.0	3
8	Mike Garrett M. Garrett	1,031	1972	SD	14	272	3.8	73.6	6	245	31	7.9	17.5	1
9	John Brockington J. Brockington	1,027	1972	GB	14	274	3.7	73.4	8	243	19	12.8	17.4	1
10	Mercury Morris M. Morris	1,000	1972	MIA	14	190	5.3	71.4	12	168	15	11.2	12.0	0
11	Dave Hampton D. Hampton	995	1972	ATL	13	230	4.3	76.5	6	244	23	10.6	18.8	1
12	Bobby Douglass B. Douglass	968	1972	CHI	14	141	6.9	69.1	8	0	0		0.0	0
13	John Riggins J. Riggins	944	1972	NYJ	12	207	4.6	78.7	7	230	21	11.0	19.2	1
14	Floyd Little F. Little	859	1972	DEN	14	216	4.0	61.4	9	367	28	13.1	26.2	4
15	Essex Johnson E. Johnson	825	1972	CIN	14	212	3.9	58.9	4	420	29	14.5	30.0	2
16	MacArthur Lane M. Lane	821	1972	GB	14	177	4.6	58.6	3	285	26	11.0	20.4	0
17	Leroy Kelly L. Kelly	811	1972	CLE	14	224	3.6	57.9	4	204	23	8.9	14.6	1
18	Art Malone A. Malone	798	1972	ATL	14	180	4.4	57.0	8	585	50	11.7	41.8	2
19	Walt Garrison W. Garrison	784	1972	DAL	14	167	4.7	56.0	7	390	37	10.5	27.9	3
20	Willie Ellison W. Ellison	764	1972	LA	13	170	4.5	58.8	5	141	23	6.1	10.8	1
21	Charlie Smith C. Smith	686	1972	OAK	14	170	4.0	49.0	8	353	28	12.6	25.2	2
22	Cid Edwards C. Edwards	679	1972	SD	12	157	4.3	56.6	5	557	40	13.9	46.4	2
23	Don McCauley D. McCauley	675	1972	BAL	14	178	3.8	48.2	2	256	30	8.5	18.3	2
24	John Fuqua J. Fuqua	665	1972	PIT	13	150	4.4	51.2	4	152	18	8.4	11.7	0
25	Altie Taylor A. Taylor	658	1972	DET	13	154	4.3	50.6	4	250	29	8.6	19.2	2

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Patriots - y	14	3	0	.824
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Jets - e	3	14	0	.176
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Rams - w	12	5	0	.706
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O.J. Simpson rushed for the most yards in 1972, with 1,251 yards.

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