Paul Krause and Johnny Robinson were tied for the most games with 2+ interceptions, with 16 games.

nfl most games with 2 interceptions player
Interpreted as:
NFL most regular-season games with 2 or more defensive interceptions player
Paul KrausePaul Krause163356621
Johnny RobinsonJohnny Robinson163446911
Ed ReedEd Reed1224353380.006262211
Ronnie LottRonnie Lott11220.022620
Dick LeBeauDick LeBeau112229211
Dave GraysonDave Grayson112432610
Bobby HuntBobby Hunt112543210
Everson WallsEverson Walls9180.020210
Dave BrownDave Brown9180.024730
Lem BarneyLem Barney92032110
Herb AdderleyHerb Adderley91945220
Bobby BoydBobby Boyd91832120
Goose GonsoulinGoose Gonsoulin92125410
Asante SamuelAsante Samuel817250250.002401010
Charles WoodsonCharles Woodson816308381.062513130
Darren SharperDarren Sharper817225270.5381210
Rod WoodsonRod Woodson8183140.0446300
Gill ByrdGill Byrd8160.017000
Darrell GreenDarrell Green8170.018420
Lionel WashingtonLionel Washington8160.013000
Deron CherryDeron Cherry8180.023400
Donnie ShellDonnie Shell8170.019610
Steve FoleySteve Foley8170.018400
Mike HaynesMike Haynes8170.024810
Thom DardenThom Darden81625511
StatMuse has game-level data for interceptions going back to the 1960 season.

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