Adrian Peterson has the most rushing yards by a running back in a game, with 296 yards against the San Diego Chargers on November 4, 2007.
Interpreted as:
NFL most rushing yards in a regular-season game for a rb| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | A. Peterson | 296 | 11/4/2007 | vs | 30 | 9.9 | 3 | 19 | 1 | 2 | 19.0 | 0 | ||
| 2 |  | J. Lewis | 295 | 9/14/2003 | vs | 30 | 9.8 | 2 | 0 | 0 | 1 | 0 | |||
| 3 | | J. Harrison | 286 | 12/20/2009 | @ | 34 | 8.4 | 3 | 12 | 2 | 3 | 6.0 | 0 | ||
| 4 | | C. Dillon | 278 | 10/22/2000 | vs | 22 | 12.6 | 2 | 0 | 0 | 0 | 0 | |||
| 5 |  | W. Payton | 275 | 11/20/1977 | vs | 40 | 6.9 | 1 | 6 | 1 | 6.0 | 0 | |||
| 6 |  | O.J. Simpson | 273 | 11/25/1976 | @ | 29 | 9.4 | 2 | 0 | 0 | 0 | ||||
| 7 | | S. Alexander | 266 | 11/11/2001 | vs | 35 | 7.6 | 3 | 7 | 1 | 1 | 7.0 | 0 | ||
| 8 | | J. Charles | 259 | 1/3/2010 | @ | 25 | 10.4 | 2 | 3 | 1 | 1 | 3.0 | 0 | ||
| 9 |  | S. Barkley | 255 | 11/24/2024 | @ | 26 | 9.8 | 2 | 47 | 4 | 4 | 11.8 | 0 | ||
| 10 |  | J. Taylor | 253 | 1/3/2021 | vs | 30 | 8.4 | 2 | 1 | 1 | 2 | 1.0 | 0 | ||
| 11 |  | D. Murray | 253 | 10/23/2011 | vs | 25 | 10.1 | 1 | 0 | 0 | 2 | 0 | |||
| 12 |  | D. Martin | 251 | 11/4/2012 | @ | 25 | 10.0 | 4 | 21 | 4 | 5 | 5.3 | 0 | ||
| 13 | | M. Anderson | 251 | 12/3/2000 | @ | 37 | 6.8 | 4 | 5 | 1 | 1 | 5.0 | 0 | ||
| 14 |  | D. Henry | 250 | 1/3/2021 | @ | 34 | 7.4 | 2 | 0 | 0 | 0 | 0 | |||
| 15 | | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 16 | | W. Ellison | 247 | 12/5/1971 | vs | 26 | 9.5 | 1 | 0 | 0 | 0 | ||||
| 17 | | C. Dillon | 246 | 12/4/1997 | vs | 39 | 6.3 | 4 | 30 | 2 | 15.0 | 0 | |||
| 18 | | J. Taylor | 244 | 11/9/2025 | vs | 32 | 7.6 | 3 | 42 | 3 | 3 | 14.0 | 0 | ||
| 19 |  | L. Tomlinson | 243 | 12/28/2003 | vs | 31 | 7.8 | 2 | 17 | 8 | 15 | 2.1 | 0 | ||
| 20 | | C. Gilchrist | 243 | 12/8/1963 | vs | 36 | 6.8 | 5 | 0 | 0 | 0 | ||||
| 21 | | D. Henry | 238 | 12/6/2018 | vs | 17 | 14.0 | 4 | 0 | 0 | 0 | 0 | |||
| 22 |  | B. Sanders | 237 | 11/13/1994 | vs | 26 | 9.1 | 0 | 16 | 1 | 16.0 | 0 | |||
| 23 |  | E. Smith | 237 | 10/31/1993 | @ | 30 | 7.9 | 1 | 0 | 0 | 0 | ||||
| 24 |  | J. Brown | 237 | 11/19/1961 | vs | 34 | 7.0 | 4 | 52 | 3 | 17.3 | 0 | |||
| 25 | | J. Brown | 237 | 11/24/1957 | vs | 31 | 7.6 | 4 | 21 | 3 | 7.0 | 0 | |||
CHI
STL
LA
TENResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More NFL News
The 49ers hope new defensive wrinkles from coordinator Raheem Morris pay off
Jets' Geno Smith focused on getting back to work after being off-field 'distraction' in offseason
Rams' Sean McVay says Aaron Donald's training is going well, but no comeback decision is imminent
A maze, underground parking and a shorter walk: Inside the Broncos’ new $175M HQ
49ers coach Kyle Shanahan takes blame for the crash that left him with a concussion
Daniel Jones, DeForest Buckner cleared to practice at Colts camp, but Alec Pierce begins on PUP
More Vikings Stats
Team Leaders 
PASS
1,632
McCarthy
RUSH
758
Mason
REC
1,048
Jefferson
Team Rankings
PPG
20.2
26th
OPP PPG
19.6
7th
RUSH YDS/G
108.3
23rd
PASS YDS/G
188.7
30th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |