O.J. Simpson has the most rushing yards for the Bills in a game, with 273 yards versus the Lions on November 25, 1976.
Interpreted as:
NFL players with most rushing yards bills and jaguars this regular-season game| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 11/25/1976 | @ | 29 | 9.4 | 2 | 0 | 0 | 0 | ||||
| 2 | | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 3 |  | C. Gilchrist | 243 | 12/8/1963 | vs | 36 | 6.8 | 5 | 0 | 0 | 0 | ||||
| 4 | | F. Taylor | 234 | 11/19/2000 | @ | 30 | 7.8 | 3 | 14 | 3 | 7 | 4.7 | 1 | ||
| 5 | | O.J. Simpson | 227 | 9/28/1975 | @ | 28 | 8.1 | 1 | 0 | 0 | 0 | ||||
| 6 |  | L. Fournette | 225 | 9/29/2019 | @ | 29 | 7.8 | 0 | 20 | 2 | 3 | 10.0 | 0 | ||
| 7 | | O.J. Simpson | 219 | 12/9/1973 | vs | 22 | 10.0 | 1 | 0 | 0 | 0 | ||||
| 8 |  | J. Cook III | 216 | 10/26/2025 | @ | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 9 | | T. Thomas | 214 | 9/24/1990 | @ | 18 | 11.9 | 0 | 5 | 3 | 1.7 | 0 | |||
| 10 | | F. Jackson | 212 | 1/3/2010 | vs | 33 | 6.4 | 0 | 15 | 2 | 2 | 7.5 | 1 | ||
| 11 | | T. Miller | 208 | 11/26/1978 | vs | 21 | 9.9 | 2 | 7 | 2 | 3.5 | 0 | |||
| 12 | | G. Bell | 206 | 11/18/1984 | vs | 27 | 7.6 | 1 | 12 | 2 | 6.0 | 1 | |||
| 13 | | O.J. Simpson | 203 | 12/5/1976 | @ | 24 | 8.5 | 1 | 12 | 2 | 6.0 | 0 | |||
| 14 | | O.J. Simpson | 200 | 12/16/1973 | @ | 34 | 5.9 | 1 | 0 | 0 | 0 | ||||
| 15 | | O.J. Simpson | 197 | 11/17/1975 | @ | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |||
| 16 | | F. Taylor | 194 | 12/21/2003 | vs | 34 | 5.7 | 1 | 31 | 2 | 2 | 15.5 | 0 | ||
| 17 | | O.J. Simpson | 189 | 10/29/1972 | vs | 22 | 8.6 | 1 | 7 | 3 | 2.3 | 0 | |||
| 18 | | M. Jones-Drew | 186 | 12/5/2010 | @ | 31 | 6.0 | 0 | 4 | 1 | 1 | 4.0 | 0 | ||
| 19 | | J. Cribbs | 185 | 12/4/1983 | @ | 36 | 5.1 | 0 | 0 | 0 | 0 | ||||
| 20 | | O.J. Simpson | 185 | 12/14/1975 | @ | 21 | 8.8 | 1 | 28 | 2 | 14.0 | 0 | |||
| 21 | | F. Taylor | 183 | 12/6/1998 | vs | 32 | 5.7 | 2 | 23 | 3 | 7.7 | 0 | |||
| 22 | | L. Fournette | 181 | 10/8/2017 | @ | 28 | 6.5 | 2 | 3 | 1 | 1 | 3.0 | 0 | ||
| 23 | | F. Taylor | 181 | 12/3/2000 | vs | 30 | 6.0 | 3 | 6 | 1 | 1 | 6.0 | 0 | ||
| 24 | | K. Davis | 181 | 11/22/1992 | vs | 20 | 9.1 | 2 | 4 | 1 | 4.0 | 0 | |||
| 25 | | J. Cook III | 179 | 12/17/2023 | vs | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 | ||
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |