Brian Westbrook, Priest Holmes and Walter Payton were tied for the most games with 100+ rushing yards and 100+ receiving yards, with 2 games.

nfl who has the most games with 100 rushing yards and 100 receiving yards
Interpreted as:
NFL who has the most regular-season games with 100 or more rushing yards and 100 or more receiving yards
WestbrookHolmesPaytonEkelerMcCaffreyGurleyFosterJohnsonThomasAddaiJacksonThomasWalkerBrooksHectorAllenJamesAndersonNelsonSimsDelaneyReed2221111111111111111111
NAMEGPRUSH YDSREC YDSATTRUSH AVGRUSH YDS/GRUSH TDRECTRGREC AVGREC YDS/GREC TD
Brian WestbrookBrian Westbrook2211224277.8105.52121618.7112.02
Priest HolmesPriest Holmes2365219517.2182.53121418.3109.52
Walter PaytonWalter Payton2241209406.0120.52923.2104.51
Austin EkelerAustin Ekeler1101112812.6101.004528.0112.01
Christian McCaffreyChristian McCaffrey1125112177.4125.01111110.2112.01
Todd GurleyTodd Gurley1118158225.4118.00101315.8158.02
Arian FosterArian Foster1115119254.6115.025523.8119.01
Chris JohnsonChris Johnson1132100265.1132.029911.1100.00
Pierre ThomasPierre Thomas1105121205.3105.00121510.1121.01
Joseph AddaiJoseph Addai1112114264.3112.005522.8114.01
Steven JacksonSteven Jackson1150102334.5150.016817.0102.01
Thurman ThomasThurman Thomas1165103256.6165.01812.9103.01
Herschel WalkerHerschel Walker1122170620.3122.01918.9170.01
James BrooksJames Brooks1163101189.1163.01616.8101.00
Johnny HectorJohnny Hector1117100186.5117.00911.1100.00
Marcus AllenMarcus Allen1102102244.3102.01617.0102.01
Lionel JamesLionel James11271181210.6127.01523.6118.01
Ottis AndersonOttis Anderson1111112244.6111.00618.7112.00
Darrin NelsonDarrin Nelson1119137167.4119.00719.6137.00
Billy SimsBilly Sims1119103254.8119.00520.6103.00
Joe DelaneyJoe Delaney1106104283.8106.00334.7104.00
Tony ReedTony Reed1106103205.3106.00812.9103.00
Tony DorsettTony Dorsett1147107159.8147.00335.7107.01
Greg PruittGreg Pruitt1121106177.1121.01715.1106.01
Larry BrownLarry Brown1150105265.8150.01335.0105.03
StatMuse has game-level data for receiving yards and rushing yards going back to the 1960 season.

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