The San Francisco 49ers have a record of 7-7 against the AFC in the regular-season and playoffs on the road since 2021.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/21/2021 | 1-0 | @ | W 30-10 | 1.000 | 3 | 25 | 333 | 200 | 50.0 | 100.0 | ||
| 2 | | 49ers | 12/12/2021 | 1-0 | @ | W 26-23 | 1.000 | 3 | 21 | 355 | 397 | 33.3 | |||
| 3 | | 49ers | 12/23/2021 | 0-1 | @ | L 17-20 | .000 | 2 | 22 | 389 | 278 | 37.5 | 50.0 | ||
| 4 | | 49ers | 9/25/2022 | 0-1 | @ | L 10-11 | .000 | 1 | 13 | 267 | 261 | 10.0 | |||
| 5 | | 49ers | 1/1/2023 | 1-0 | @ | W 37-34 | 1.000 | 4 | 27 | 454 | 500 | 50.0 | |||
| 6 | | 49ers | 9/10/2023 | 1-0 | @ | W 30-7 | 1.000 | 3 | 22 | 391 | 239 | 46.2 | 100.0 | ||
| 7 | | 49ers | 10/15/2023 | 0-1 | @ | L 17-19 | .000 | 2 | 15 | 215 | 334 | 25.0 | |||
| 8 | | 49ers | 11/12/2023 | 1-0 | @ | W 34-3 | 1.000 | 4 | 20 | 437 | 221 | 33.3 | 50.0 | ||
| 9 | | 49ers | 2/11/2024 | 0-1 | @ | L 22-25 | .000 | 2 | 23 | 382 | 455 | 25.0 | 100.0 | ||
| 10 | | 49ers | 12/1/2024 | 0-1 | @ | L 10-35 | .000 | 1 | 15 | 239 | 372 | 30.0 | 100.0 | ||
| 11 | | 49ers | 12/22/2024 | 0-1 | @ | L 17-29 | .000 | 2 | 20 | 374 | 381 | 38.5 | 0.0 | ||
| 12 | | 49ers | 10/26/2025 | 0-1 | @ | L 15-26 | .000 | 2 | 12 | 223 | 475 | 33.3 | 0.0 | ||
| 13 | | 49ers | 11/30/2025 | 1-0 | @ | W 26-8 | 1.000 | 3 | 19 | 252 | 253 | 64.7 | |||
| 14 | | 49ers | 12/22/2025 | 1-0 | @ | W 48-27 | 1.000 | 6 | 28 | 440 | 312 | 63.6 | 100.0 | ||
| Average | .500 | 2.7 | 20.1 | 339.4 | 334.1 | 39.5 | 7.1 | ||||||||
| Total | 7-7 | .500 | 38 | 282 | 4,751 | 4,678 | 39.5 | 63.6 |
More 49ers Stats
Team Leaders 
PASS
402
Purdy
RUSH
83
McCaffrey
REC
112
Robinson
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
