| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | San Francisco 49ers | -181 | vs |  Jacksonville Jaguars | +148 | WK 4 | Sun, Sep 28, 2025 | 4:05 PM | -3.5 | 47.0 |
| 2 | | San Francisco 49ers | +134 | @ |  Los Angeles Rams | -158 | WK 5 | Thu, Oct 2, 2025 | 8:15 PM | +3.0 | 47.0 |
| 3 | | San Francisco 49ers | -105 | @ |  Tampa Bay Buccaneers | -125 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +1.0 | 48.5 |
| 4 | | San Francisco 49ers | -270 | vs |  Atlanta Falcons | +205 | WK 7 | Sun, Oct 19, 2025 | 8:20 PM | -6.0 | 47.5 |
| 5 | | San Francisco 49ers | -105 | @ |  Houston Texans | -125 | WK 8 | Sun, Oct 26, 2025 | 1:00 PM | +1.0 | 45.0 |
| 6 | | San Francisco 49ers | -135 | vs | Los Angeles Rams | +105 | WK 10 | Sun, Nov 9, 2025 | 4:25 PM | -1.5 | 46.5 |
| 7 | | San Francisco 49ers | -130 | @ |  Arizona Cardinals | +100 | WK 11 | Sun, Nov 16, 2025 | 4:05 PM | -1.5 | 47.5 |
Betting lines shown represent consensus, closing odds.
More 49ers Stats
Team Rankings
PPG
19.7
23rd
OPP PPG
16.3
3rd
RUSH YDS/G
89.7
26th
PASS YDS/G
280.0
3rd
Seahawks 
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
 Packers | 2 | 1 | 0 | .667 |
 Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
 49ers | 3 | 0 | 0 | 1.000 |
| Rams | 2 | 1 | 0 | .667 |
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