| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | San Francisco 49ers | +208 | @ |  Los Angeles Rams | -258 | WK 5 | Thu, Oct 2, 2025 | 8:15 PM | +5.5 | 47.5 |
| 2 |  | Minnesota Vikings | -198 | @ |  Cleveland Browns | +163 | WK 5 | Sun, Oct 5, 2025 | 9:30 AM | -3.5 | 36.5 |
| 3 |  | Houston Texans | +141 | @ |  Baltimore Ravens | -170 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +3.5 | 43.5 |
| 4 |  | New York Giants | -106 | @ |  New Orleans Saints | -113 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +1.5 | 40.5 |
| 5 |  | Denver Broncos | +181 | @ |  Philadelphia Eagles | -220 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +4.5 | 43.5 |
| 6 |  | Dallas Cowboys | -147 | @ |  New York Jets | +123 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | -2.5 | 46.5 |
| 7 |  | Las Vegas Raiders | +241 | @ |  Indianapolis Colts | -302 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +6.5 | 48.0 |
| 8 |  | Miami Dolphins | -106 | @ |  Carolina Panthers | -113 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +1.5 | 45.5 |
| 9 |  | Tennessee Titans | +357 | @ |  Arizona Cardinals | -467 | WK 5 | Sun, Oct 5, 2025 | 4:05 PM | +8.5 | 41.5 |
| 10 |  | Tampa Bay Buccaneers | +148 | @ |  Seattle Seahawks | -177 | WK 5 | Sun, Oct 5, 2025 | 4:05 PM | +3.5 | 44.5 |
| 11 |  | Detroit Lions | -478 | @ |  Cincinnati Bengals | +363 | WK 5 | Sun, Oct 5, 2025 | 4:25 PM | -9.5 | 49.5 |
| 12 |  | Washington Commanders | +125 | @ |  Los Angeles Chargers | -149 | WK 5 | Sun, Oct 5, 2025 | 4:25 PM | +2.5 | 47.5 |
| 13 |  | New England Patriots | +325 | @ |  Buffalo Bills | -417 | WK 5 | Sun, Oct 5, 2025 | 8:20 PM | +7.5 | 49.5 |
| 14 |  | Kansas City Chiefs | -182 | @ |  Jacksonville Jaguars | +152 | WK 5 | Mon, Oct 6, 2025 | 8:15 PM | -3.5 | 45.5 |
| 15 |  | Philadelphia Eagles | -333 | @ |  New York Giants | +240 | WK 6 | Thu, Oct 9, 2025 | 8:15 PM | -7.0 | 44.5 |
| 16 | | Denver Broncos | -294 | @ | New York Jets | +220 | WK 6 | Sun, Oct 12, 2025 | 9:30 AM | -6.0 | 41.5 |
| 17 |  | Arizona Cardinals | -120 | @ | Indianapolis Colts | -110 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | -1.0 | 47.0 |
| 18 |  | Los Angeles Rams | +175 | @ | Baltimore Ravens | -227 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +4.5 | 49.5 |
| 19 |  | Cleveland Browns | +205 | @ |  Pittsburgh Steelers | -270 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +6.0 | 41.5 |
| 20 |  | Seattle Seahawks | -110 | @ | Jacksonville Jaguars | -120 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +1.0 | 46.5 |
| 21 |  | Los Angeles Chargers | -125 | @ |  Miami Dolphins | -105 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | -1.0 | 45.5 |
| 22 | | Dallas Cowboys | -125 | @ | Carolina Panthers | +105 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | -1.5 | 47.5 |
| 23 | | New England Patriots | -175 | @ | New Orleans Saints | +140 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | -3.5 | 42.5 |
| 24 | | Tennessee Titans | +140 | @ |  Las Vegas Raiders | -175 | WK 6 | Sun, Oct 12, 2025 | 4:05 PM | +3.5 | 44.5 |
| 25 | | San Francisco 49ers | -105 | @ |  Tampa Bay Buccaneers | -125 | WK 6 | Sun, Oct 12, 2025 | 4:25 PM | +1.0 | 48.5 |
Betting lines shown represent consensus, closing odds.
More 49ers Stats
Team Rankings
PPG
20.0
23rd
OPP PPG
18.8
7th
RUSH YDS/G
88.0
28th
PASS YDS/G
287.3
2nd
HOU 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 1 | 0 | .750 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
 49ers | 3 | 1 | 0 | .750 |
| Seahawks | 3 | 1 | 0 | .750 |
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